UniProt data
UniProt name: MYP0_HUMAN (P25189)
MPZ
Homo sapiens (Human).
Creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae.
Isoform L-MPZ: Myelin membrane {ECO:0000269|PubMed:22457349}; Single-pass type I membrane protein {ECO:0000269|PubMed:22457349}.
- 154-179, 26 AA, Helical. {ECO:0000255}.
248 AA
10 20 30 40 50 60
MAPGAPSSSP SPILAVLLFS SLVLSPAQAI VVYTDREVHG AVGSRVTLHC SFWSSEWVSD
70 80 90 100 110 120
DISFTWRYQP EGGRDAISIF HYAKGQPYID EVGTFKERIQ WVGDPRWKDG SIVIHNLDYS
130 140 150 160 170 180
DNGTFTCDVK NPPDIVGKTS QVTLYVFEKV PTRYGVVLGA VIGGVLGVVL LLLLLFYVVR
190 200 210 220 230 240
YCWLRRQAAL QRRLSAMEKG KLHKPGKDAS KRGRQTPVLY AMLDHSRSTK AVSEKKAKGL
GESRKDKK
CATM prediction
The sequence of MYP0_HUMAN returned 13 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # |
Sequence and interface |
d |
θ |
Z' |
ω' |
Score |
| |
160 170 180
+ | + | + | |
(Å) |
(°) |
(Å) |
(°) |
|
| Model 1 |
ATRYGVVLGAVIGGVLGVVLLLLLLFYVVRYC |
6.4 |
-34.0° |
0.1 |
57.0 |
-33.4 |
| Model 2 |
ATRYGVVLGAVIGGVLGVVLLLLLLFYVVRYC |
6.8 |
-35.0° |
6.0 |
48.8 |
-25.3 |
| Model 3 |
ATRYGVVLGAVIGGVLGVVLLLLLLFYVVRYC |
6.3 |
-44.0° |
1.8 |
59.0 |
-24.2 |
| Model 4 |
ATRYGVVLGAVIGGVLGVVLLLLLLFYVVRYC |
6.4 |
-47.2° |
4.8 |
55.8 |
-22.0 |
| Model 5 |
ATRYGVVLGAVIGGVLGVVLLLLLLFYVVRYC |
6.5 |
-50.8° |
3.8 |
55.0 |
-20.1 |
| Model 6 |
ATRYGVVLGAVIGGVLGVVLLLLLLFYVVRYC |
7.4 |
-24.9° |
1.3 |
48.4 |
-18.4 |
| Model 7 |
ATRYGVVLGAVIGGVLGVVLLLLLLFYVVRYC |
6.6 |
-55.1° |
5.6 |
39.8 |
-17.0 |
| Model 8 |
ATRYGVVLGAVIGGVLGVVLLLLLLFYVVRYC |
6.3 |
-50.9° |
3.3 |
48.1 |
-16.4 |
| Model 9 |
ATRYGVVLGAVIGGVLGVVLLLLLLFYVVRYC |
7.4 |
-25.0° |
1.2 |
49.0 |
-12.1 |
| Model 10 |
ATRYGVVLGAVIGGVLGVVLLLLLLFYVVRYC |
7.0 |
-38.0° |
1.5 |
59.0 |
-10.8 |
| Model 11 |
ATRYGVVLGAVIGGVLGVVLLLLLLFYVVRYC |
7.4 |
-54.0° |
3.6 |
49.0 |
-6.6 |
| Model 12 |
ATRYGVVLGAVIGGVLGVVLLLLLLFYVVRYC |
6.9 |
-52.0° |
1.4 |
57.0 |
-5.3 |
| Model 13 |
ATRYGVVLGAVIGGVLGVVLLLLLLFYVVRYC |
7.2 |
-43.8° |
4.9 |
43.9 |
-1.8 |
| Prolines* |
PTRYGVVLGAVIGGVLGVVLLLLLLFYVVRYC |
|
|
|
|
|
* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Click on the image to enlarge
PDB, PyMOL session
| Donor |
Acceptor |
Distance |
| B, 156, VAL, HA |
A, 155, GLY, O |
2.69Å |
| B, 159, GLY, HA1 |
A, 156, VAL, O |
2.67Å |
| B, 160, ALA, HA |
A, 159, GLY, O |
2.49Å |
| B, 163, GLY, HA1 |
A, 160, ALA, O |
3.42Å |
| A, 156, VAL, HA |
B, 155, GLY, O |
2.69Å |
| A, 159, GLY, HA1 |
B, 156, VAL, O |
2.67Å |
| A, 160, ALA, HA |
B, 159, GLY, O |
2.49Å |
| A, 163, GLY, HA1 |
B, 160, ALA, O |
3.42Å |
MODEL 2 DETAILS
Click on the image to enlarge
PDB, PyMOL session
| Donor |
Acceptor |
Distance |
| B, 156, VAL, HA |
A, 155, GLY, O |
2.50Å |
| B, 159, GLY, HA1 |
A, 156, VAL, O |
3.21Å |
| A, 156, VAL, HA |
B, 155, GLY, O |
2.50Å |
| A, 159, GLY, HA1 |
B, 156, VAL, O |
3.21Å |
MODEL 3 DETAILS
Click on the image to enlarge
PDB, PyMOL session
| Donor |
Acceptor |
Distance |
| B, 156, VAL, HA |
A, 155, GLY, O |
2.64Å |
| B, 159, GLY, HA1 |
A, 156, VAL, O |
2.57Å |
| B, 160, ALA, HA |
A, 159, GLY, O |
2.84Å |
| A, 156, VAL, HA |
B, 155, GLY, O |
2.64Å |
| A, 159, GLY, HA1 |
B, 156, VAL, O |
2.57Å |
| A, 160, ALA, HA |
B, 159, GLY, O |
2.84Å |
MODEL 4 DETAILS
Click on the image to enlarge
PDB, PyMOL session
| Donor |
Acceptor |
Distance |
| B, 159, GLY, HA1 |
A, 156, VAL, O |
2.92Å |
| B, 160, ALA, HA |
A, 159, GLY, O |
2.37Å |
| B, 163, GLY, HA1 |
A, 160, ALA, O |
2.99Å |
| A, 159, GLY, HA1 |
B, 156, VAL, O |
2.92Å |
| A, 160, ALA, HA |
B, 159, GLY, O |
2.37Å |
| A, 163, GLY, HA1 |
B, 160, ALA, O |
2.99Å |
MODEL 5 DETAILS
Click on the image to enlarge
PDB, PyMOL session
| Donor |
Acceptor |
Distance |
| B, 156, VAL, HA |
A, 155, GLY, O |
2.62Å |
| B, 159, GLY, HA1 |
A, 156, VAL, O |
2.68Å |
| A, 156, VAL, HA |
B, 155, GLY, O |
2.62Å |
| A, 159, GLY, HA1 |
B, 156, VAL, O |
2.68Å |
MODEL 6 DETAILS
Click on the image to enlarge
PDB, PyMOL session
| Donor |
Acceptor |
Distance |
| B, 156, VAL, HA |
A, 155, GLY, O |
3.47Å |
| B, 160, ALA, HA |
A, 159, GLY, O |
3.50Å |
| A, 156, VAL, HA |
B, 155, GLY, O |
3.47Å |
| A, 160, ALA, HA |
B, 159, GLY, O |
3.50Å |
MODEL 7 DETAILS
Click on the image to enlarge
PDB, PyMOL session
| Donor |
Acceptor |
Distance |
| B, 163, GLY, HA1 |
A, 160, ALA, O |
3.03Å |
| B, 164, GLY, HA2 |
A, 163, GLY, O |
2.52Å |
| B, 167, GLY, HA1 |
A, 164, GLY, O |
3.15Å |
| A, 163, GLY, HA1 |
B, 160, ALA, O |
3.03Å |
| A, 164, GLY, HA2 |
B, 163, GLY, O |
2.52Å |
| A, 167, GLY, HA1 |
B, 164, GLY, O |
3.15Å |
MODEL 8 DETAILS
Click on the image to enlarge
PDB, PyMOL session
| Donor |
Acceptor |
Distance |
| B, 160, ALA, HA |
A, 159, GLY, O |
2.39Å |
| B, 163, GLY, HA1 |
A, 160, ALA, O |
2.36Å |
| B, 164, GLY, HA2 |
A, 163, GLY, O |
3.42Å |
| A, 160, ALA, HA |
B, 159, GLY, O |
2.39Å |
| A, 163, GLY, HA1 |
B, 160, ALA, O |
2.36Å |
| A, 164, GLY, HA2 |
B, 163, GLY, O |
3.42Å |
MODEL 9 DETAILS
Click on the image to enlarge
PDB, PyMOL session
| Donor |
Acceptor |
Distance |
| B, 156, VAL, HA |
A, 155, GLY, O |
3.38Å |
| A, 156, VAL, HA |
B, 155, GLY, O |
3.38Å |
MODEL 10 DETAILS
Click on the image to enlarge
PDB, PyMOL session
| Donor |
Acceptor |
Distance |
| B, 156, VAL, HA |
A, 155, GLY, O |
3.38Å |
| A, 156, VAL, HA |
B, 155, GLY, O |
3.38Å |
MODEL 11 DETAILS
Click on the image to enlarge
PDB, PyMOL session
| Donor |
Acceptor |
Distance |
| B, 161, VAL, HA |
A, 160, ALA, O |
3.36Å |
| B, 164, GLY, HA1 |
A, 161, VAL, O |
3.47Å |
| A, 161, VAL, HA |
B, 160, ALA, O |
3.36Å |
| A, 164, GLY, HA1 |
B, 161, VAL, O |
3.47Å |
MODEL 12 DETAILS
Click on the image to enlarge
PDB, PyMOL session
| Donor |
Acceptor |
Distance |
| B, 156, VAL, HA |
A, 155, GLY, O |
3.36Å |
| A, 156, VAL, HA |
B, 155, GLY, O |
3.36Å |
MODEL 13 DETAILS
Click on the image to enlarge
PDB, PyMOL session
| Donor |
Acceptor |
Distance |
| B, 156, VAL, HA |
A, 155, GLY, O |
3.06Å |
| B, 159, GLY, HA1 |
A, 156, VAL, O |
3.32Å |
| A, 156, VAL, HA |
B, 155, GLY, O |
3.06Å |
| A, 159, GLY, HA1 |
B, 156, VAL, O |
3.32Å |
