UniProt data
UniProt name: IL4RA_HUMAN (P24394)
Gene name: IL4R; Synonyms=IL4RA; ORFNames=582J2.1
Organism: Homo sapiens (Human).
Function: Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells. {ECO:0000269|PubMed:8124718}.
Subcellular location: Isoform 2: Secreted.
Transmembrane domains:
- 233-256, 24 AA, Helical. {ECO:0000255}.
Sequence: 825 AA
10 20 30 40 50 60
MGWLCSGLLF PVSCLVLLQV ASSGNMKVLQ EPTCVSDYMS ISTCEWKMNG PTNCSTELRL
70 80 90 100 110 120
LYQLVFLLSE AHTCIPENNG GAGCVCHLLM DDVVSADNYT LDLWAGQQLL WKGSFKPSEH
130 140 150 160 170 180
VKPRAPGNLT VHTNVSDTLL LTWSNPYPPD NYLYNHLTYA VNIWSENDPA DFRIYNVTYL
190 200 210 220 230 240
EPSLRIAAST LKSGISYRAR VRAWAQCYNT TWSEWSPSTK WHNSYREPFE QHLLLGVSVS
250 260 270 280 290 300
CIVILAVCLL CYVSITKIKK EWWDQIPNPA RSRLVAIIIQ DAQGSQWEKR SRGQEPAKCP
310 320 330 340 350 360
HWKNCLTKLL PCFLEHNMKR DEDPHKAAKE MPFQGSGKSA WCPVEISKTV LWPESISVVR
370 380 390 400 410 420
CVELFEAPVE CEEEEEVEEE KGSFCASPES SRDDFQEGRE GIVARLTESL FLDLLGEENG
430 440 450 460 470 480
GFCQQDMGES CLLPPSGSTS AHMPWDEFPS AGPKEAPPWG KEQPLHLEPS PPASPTQSPD
490 500 510 520 530 540
NLTCTETPLV IAGNPAYRSF SNSLSQSPCP RELGPDPLLA RHLEEVEPEM PCVPQLSEPT
550 560 570 580 590 600
TVPQPEPETW EQILRRNVLQ HGAAAAPVSA PTSGYQEFVH AVEQGGTQAS AVVGLGPPGE
610 620 630 640 650 660
AGYKAFSSLL ASSAVSPEKC GFGASSGEEG YKPFQDLIPG CPGDPAPVPV PLFTFGLDRE
670 680 690 700 710 720
PPRSPQSSHL PSSSPEHLGL EPGEKVEDMP KPPLPQEQAT DPLVDSLGSG IVYSALTCHL
730 740 750 760 770 780
CGHLKQCHGQ EDGGQTPVMA SPCCGCCCGD RSSPPTTPLR APDPSPGGVP LEASLCPASL
790 800 810 820
APSGISEKSK SSSSFHPAPG NAQSSSQTPK IVNFVSVGPT YMRVS
CATM prediction
The sequence of IL4RA_HUMAN returned 1 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 230 240 250 | + | + | + |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | EQHLLLGVSVSCIVILAVCLLCYVSITKIK | 7.0 | -44.0° | 4.9 | 44.1 | -8.7 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 236, GLY, HA1 | A, 233, LEU, O | 3.39Å |
| B, 240, SER, HG1 | A, 240, SER, OG | 1.98Å |
| A, 236, GLY, HA1 | B, 233, LEU, O | 3.39Å |
| A, 237, VAL, HA | B, 240, SER, OG | 3.15Å |