UniProt data
UniProt name: TNFL4_HUMAN (P23510)
Gene name: TNFSF4; Synonyms=TXGP1
Organism: Homo sapiens (Human).
Function: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
Subcellular location: Membrane; Single-pass type II membrane protein.
Transmembrane domains:
- 24-50, 27 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.
Sequence: 183 AA
10 20 30 40 50 60
MERVQPLEEN VGNAARPRFE RNKLLLVASV IQGLGLLLCF TYICLHFSAL QVSHRYPRIQ
70 80 90 100 110 120
SIKVQFTEYK KEKGFILTSQ KEDEIMKVQN NSVIINCDGF YLISLKGYFS QEVNISLHYQ
130 140 150 160 170 180
KDEEPLFQLK KVRSVNSLMV ASLTYKDKVY LNVTTDNTSL DDFHVNGGEL ILIHQNPGEF
CVL
CATM prediction
The sequence of TNFL4_HUMAN returned 1 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 30 40 50 + | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | RNKLLLVASVIQGLGLLLCFTYICLHFSALQVS | 7.3 | -47.0° | 2.3 | 44.7 | -0.8 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 32, GLN, HA | A, 31, ILE, O | 3.31Å |
| B, 35, GLY, HA1 | A, 32, GLN, O | 3.09Å |
| B, 36, LEU, HA | A, 35, GLY, O | 3.46Å |
| A, 32, GLN, HA | B, 31, ILE, O | 3.31Å |
| A, 35, GLY, HA1 | B, 32, GLN, O | 3.09Å |
| A, 36, LEU, HA | B, 35, GLY, O | 3.46Å |