Macrophage mannose receptor 1

UniProt data

UniProt name: MRC1_HUMAN (P22897)

Gene name: MRC1; Synonyms=CLEC13D, CLEC13DL, MRC1L1

Organism: Homo sapiens (Human).

Function: (Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens. Acts as a receptor for Dengue virus envelope protein E (PubMed:18266465). Interacts with hepatitis B virus envelope protein (PubMed:19683778). {ECO:0000269|PubMed:18266465, ECO:0000269|PubMed:19683778}.

Subcellular location: Endosome membrane {ECO:0000269|PubMed:20035344}; Single-pass type I membrane protein {ECO:0000269|PubMed:20035344}. Cell membrane {ECO:0000269|PubMed:20035344}; Single-pass type I membrane protein {ECO:0000269|PubMed:20035344}.

Transmembrane domains:

  1. 1390-1410, 21 AA, Helical. {ECO:0000255}.

Sequence: 1456 AA

10 20 30 40 50 60 MRLPLLLVFA SVIPGAVLLL DTRQFLIYNE DHKRCVDAVS PSAVQTAACN QDAESQKFRW 70 80 90 100 110 120 VSESQIMSVA FKLCLGVPSK TDWVAITLYA CDSKSEFQKW ECKNDTLLGI KGEDLFFNYG 130 140 150 160 170 180 NRQEKNIMLY KGSGLWSRWK IYGTTDNLCS RGYEAMYTLL GNANGATCAF PFKFENKWYA 190 200 210 220 230 240 DCTSAGRSDG WLWCGTTTDY DTDKLFGYCP LKFEGSESLW NKDPLTSVSY QINSKSALTW 250 260 270 280 290 300 HQARKSCQQQ NAELLSITEI HEQTYLTGLT SSLTSGLWIG LNSLSFNSGW QWSDRSPFRY 310 320 330 340 350 360 LNWLPGSPSA EPGKSCVSLN PGKNAKWENL ECVQKLGYIC KKGNTTLNSF VIPSESDVPT 370 380 390 400 410 420 HCPSQWWPYA GHCYKIHRDE KKIQRDALTT CRKEGGDLTS IHTIEELDFI ISQLGYEPND 430 440 450 460 470 480 ELWIGLNDIK IQMYFEWSDG TPVTFTKWLR GEPSHENNRQ EDCVVMKGKD GYWADRGCEW 490 500 510 520 530 540 PLGYICKMKS RSQGPEIVEV EKGCRKGWKK HHFYCYMIGH TLSTFAEANQ TCNNENAYLT 550 560 570 580 590 600 TIEDRYEQAF LTSFVGLRPE KYFWTGLSDI QTKGTFQWTI EEEVRFTHWN SDMPGRKPGC 610 620 630 640 650 660 VAMRTGIAGG LWDVLKCDEK AKFVCKHWAE GVTHPPKPTT TPEPKCPEDW GASSRTSLCF 670 680 690 700 710 720 KLYAKGKHEK KTWFESRDFC RALGGDLASI NNKEEQQTIW RLITASGSYH KLFWLGLTYG 730 740 750 760 770 780 SPSEGFTWSD GSPVSYENWA YGEPNNYQNV EYCGELKGDP TMSWNDINCE HLNNWICQIQ 790 800 810 820 830 840 KGQTPKPEPT PAPQDNPPVT EDGWVIYKDY QYYFSKEKET MDNARAFCKR NFGDLVSIQS 850 860 870 880 890 900 ESEKKFLWKY VNRNDAQSAY FIGLLISLDK KFAWMDGSKV DYVSWATGEP NFANEDENCV 910 920 930 940 950 960 TMYSNSGFWN DINCGYPNAF ICQRHNSSIN ATTVMPTMPS VPSGCKEGWN FYSNKCFKIF 970 980 990 1000 1010 1020 GFMEEERKNW QEARKACIGF GGNLVSIQNE KEQAFLTYHM KDSTFSAWTG LNDVNSEHTF 1030 1040 1050 1060 1070 1080 LWTDGRGVHY TNWGKGYPGG RRSSLSYEDA DCVVIIGGAS NEAGKWMDDT CDSKRGYICQ 1090 1100 1110 1120 1130 1140 TRSDPSLTNP PATIQTDGFV KYGKSSYSLM RQKFQWHEAE TYCKLHNSLI ASILDPYSNA 1150 1160 1170 1180 1190 1200 FAWLQMETSN ERVWIALNSN LTDNQYTWTD KWRVRYTNWA ADEPKLKSAC VYLDLDGYWK 1210 1220 1230 1240 1250 1260 TAHCNESFYF LCKRSDEIPA TEPPQLPGRC PESDHTAWIP FHGHCYYIES SYTRNWGQAS 1270 1280 1290 1300 1310 1320 LECLRMGSSL VSIESAAESS FLSYRVEPLK SKTNFWIGLF RNVEGTWLWI NNSPVSFVNW 1330 1340 1350 1360 1370 1380 NTGDPSGERN DCVALHASSG FWSNIHCSSY KGYICKRPKI IDAKPTHELL TTKADTRKMD 1390 1400 1410 1420 1430 1440 PSKPSSNVAG VVIIVILLIL TGAGLAAYFF YKKRRVHLPQ EGAFENTLYF NSQSSPGTSD 1450 MKDLVGNIEQ NEHSVI

CATM prediction

The sequence of MRC1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     1390      1400      1410
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 NVAGVVIIVILLILTGAGLAAYFFYKK 6.6 -55.2° 0.9 50.0 -21.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1399, ILE, HA A, 1398, LEU, O 3.30Å
B, 1402, GLY, HA1 A, 1399, ILE, O 2.63Å
B, 1403, ALA, HA A, 1402, GLY, O 3.00Å
A, 1399, ILE, HA B, 1398, LEU, O 3.30Å
A, 1402, GLY, HA1 B, 1399, ILE, O 2.63Å
A, 1403, ALA, HA B, 1402, GLY, O 3.00Å