Arylacetamide deacetylase

UniProt data

UniProt name: AAAD_HUMAN (P22760)

Gene name: AADAC; Synonyms=DAC

Organism: Homo sapiens (Human).

Function: Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity. {ECO:0000269|PubMed:17936933, ECO:0000269|PubMed:19339378, ECO:0000269|PubMed:22207054, ECO:0000269|PubMed:22415931, ECO:0000269|PubMed:23542347}.

Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane; Single-pass type II membrane protein.

Transmembrane domains:

  1. 6-23, 18 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 399 AA

10 20 30 40 50 60 MGRKSLYLLI VGILIAYYIY TPLPDNVEEP WRMMWINAHL KTIQNLATFV ELLGLHHFMD 70 80 90 100 110 120 SFKVVGSFDE VPPTSDENVT VTETKFNNIL VRVYVPKRKS EALRRGLFYI HGGGWCVGSA 130 140 150 160 170 180 ALSGYDLLSR WTADRLDAVV VSTNYRLAPK YHFPIQFEDV YNALRWFLRK KVLAKYGVNP 190 200 210 220 230 240 ERIGISGDSA GGNLAAAVTQ QLLDDPDVKI KLKIQSLIYP ALQPLDVDLP SYQENSNFLF 250 260 270 280 290 300 LSKSLMVRFW SEYFTTDRSL EKAMLSRQHV PVESSHLFKF VNWSSLLPER FIKGHVYNNP 310 320 330 340 350 360 NYGSSELAKK YPGFLDVRAA PLLADDNKLR GLPLTYVITC QYDLLRDDGL MYVTRLRNTG 370 380 390 VQVTHNHVED GFHGAFSFLG LKISHRLINQ YIEWLKENL

CATM prediction

The sequence of AAAD_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         10        20     
  +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 RKSLYLLIVGILIAYYIYTALADN 7.3 -47.6° 1.4 44.8 -3.8
Prolines* RKSLYLLIVGILIAYYIYTPLPDN          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 12, GLY, HA1 A, 9, LEU, O 3.19Å
B, 13, ILE, HA A, 12, GLY, O 3.39Å
A, 12, GLY, HA1 B, 9, LEU, O 3.19Å
A, 13, ILE, HA B, 12, GLY, O 3.39Å