Cadherin-3

UniProt data

UniProt name: CADH3_HUMAN (P22223)

Gene name: CDH3; Synonyms=CDHP

Organism: Homo sapiens (Human).

Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Subcellular location: Cell membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 655-677, 23 AA, Helical. {ECO:0000255}.

Sequence: 829 AA

10 20 30 40 50 60 MGLPRGPLAS LLLLQVCWLQ CAASEPCRAV FREAEVTLEA GGAEQEPGQA LGKVFMGCPG 70 80 90 100 110 120 QEPALFSTDN DDFTVRNGET VQERRSLKER NPLKIFPSKR ILRRHKRDWV VAPISVPENG 130 140 150 160 170 180 KGPFPQRLNQ LKSNKDRDTK IFYSITGPGA DSPPEGVFAV EKETGWLLLN KPLDREEIAK 190 200 210 220 230 240 YELFGHAVSE NGASVEDPMN ISIIVTDQND HKPKFTQDTF RGSVLEGVLP GTSVMQVTAT 250 260 270 280 290 300 DEDDAIYTYN GVVAYSIHSQ EPKDPHDLMF TIHRSTGTIS VISSGLDREK VPEYTLTIQA 310 320 330 340 350 360 TDMDGDGSTT TAVAVVEILD ANDNAPMFDP QKYEAHVPEN AVGHEVQRLT VTDLDAPNSP 370 380 390 400 410 420 AWRATYLIMG GDDGDHFTIT THPESNQGIL TTRKGLDFEA KNQHTLYVEV TNEAPFVLKL 430 440 450 460 470 480 PTSTATIVVH VEDVNEAPVF VPPSKVVEVQ EGIPTGEPVC VYTAEDPDKE NQKISYRILR 490 500 510 520 530 540 DPAGWLAMDP DSGQVTAVGT LDREDEQFVR NNIYEVMVLA MDNGSPPTTG TGTLLLTLID 550 560 570 580 590 600 VNDHGPVPEP RQITICNQSP VRQVLNITDK DLSPHTSPFQ AQLTDDSDIY WTAEVNEEGD 610 620 630 640 650 660 TVVLSLKKFL KQDTYDVHLS LSDHGNKEQL TVIRATVCDC HGHVETCPGP WKGGFILPVL 670 680 690 700 710 720 GAVLALLFLL LVLLLLVRKK RKIKEPLLLP EDDTRDNVFY YGEEGGGEED QDYDITQLHR 730 740 750 760 770 780 GLEARPEVVL RNDVAPTIIP TPMYRPRPAN PDEIGNFIIE NLKAANTDPT APPYDTLLVF 790 800 810 820 DYEGSGSDAA SLSSLTSSAS DQDQDYDYLN EWGSRFKKLA DMYGGGEDD

CATM prediction

The sequence of CADH3_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          660       670       6
   +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 KGGFILAVLGAVLALLFLLLVLLLLVRKK 6.9 -49.1° 2.9 32.0 -15.8
Model 2 KGGFILAVLGAVLALLFLLLVLLLLVRKK 6.8 +38.0° 4.0 77.0 -3.6
Prolines* KGGFILPVLGAVLALLFLLLVLLLLVRKK          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 658, ALA, HA A, 657, LEU, O 3.20Å
B, 661, GLY, HA1 A, 658, ALA, O 3.01Å
A, 658, ALA, HA B, 657, LEU, O 3.20Å
A, 661, GLY, HA1 B, 658, ALA, O 3.01Å