Receptor tyrosine-protein kinase erbB-3

UniProt data

UniProt name: ERBB3_HUMAN (P21860)

Gene name: ERBB3; Synonyms=HER3

Organism: Homo sapiens (Human).

Function: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). {ECO:0000269|PubMed:15358134, ECO:0000269|PubMed:20682778}.

Subcellular location: Isoform 2: Secreted.

Transmembrane domains:

  1. 644-664, 21 AA, Helical. {ECO:0000255}.

Sequence: 1342 AA

10 20 30 40 50 60 MRANDALQVL GLLFSLARGS EVGNSQAVCP GTLNGLSVTG DAENQYQTLY KLYERCEVVM 70 80 90 100 110 120 GNLEIVLTGH NADLSFLQWI REVTGYVLVA MNEFSTLPLP NLRVVRGTQV YDGKFAIFVM 130 140 150 160 170 180 LNYNTNSSHA LRQLRLTQLT EILSGGVYIE KNDKLCHMDT IDWRDIVRDR DAEIVVKDNG 190 200 210 220 230 240 RSCPPCHEVC KGRCWGPGSE DCQTLTKTIC APQCNGHCFG PNPNQCCHDE CAGGCSGPQD 250 260 270 280 290 300 TDCFACRHFN DSGACVPRCP QPLVYNKLTF QLEPNPHTKY QYGGVCVASC PHNFVVDQTS 310 320 330 340 350 360 CVRACPPDKM EVDKNGLKMC EPCGGLCPKA CEGTGSGSRF QTVDSSNIDG FVNCTKILGN 370 380 390 400 410 420 LDFLITGLNG DPWHKIPALD PEKLNVFRTV REITGYLNIQ SWPPHMHNFS VFSNLTTIGG 430 440 450 460 470 480 RSLYNRGFSL LIMKNLNVTS LGFRSLKEIS AGRIYISANR QLCYHHSLNW TKVLRGPTEE 490 500 510 520 530 540 RLDIKHNRPR RDCVAEGKVC DPLCSSGGCW GPGPGQCLSC RNYSRGGVCV THCNFLNGEP 550 560 570 580 590 600 REFAHEAECF SCHPECQPME GTATCNGSGS DTCAQCAHFR DGPHCVSSCP HGVLGAKGPI 610 620 630 640 650 660 YKYPDVQNEC RPCHENCTQG CKGPELQDCL GQTLVLIGKT HLTMALTVIA GLVVIFMMLG 670 680 690 700 710 720 GTFLYWRGRR IQNKRAMRRY LERGESIEPL DPSEKANKVL ARIFKETELR KLKVLGSGVF 730 740 750 760 770 780 GTVHKGVWIP EGESIKIPVC IKVIEDKSGR QSFQAVTDHM LAIGSLDHAH IVRLLGLCPG 790 800 810 820 830 840 SSLQLVTQYL PLGSLLDHVR QHRGALGPQL LLNWGVQIAK GMYYLEEHGM VHRNLAARNV 850 860 870 880 890 900 LLKSPSQVQV ADFGVADLLP PDDKQLLYSE AKTPIKWMAL ESIHFGKYTH QSDVWSYGVT 910 920 930 940 950 960 VWELMTFGAE PYAGLRLAEV PDLLEKGERL AQPQICTIDV YMVMVKCWMI DENIRPTFKE 970 980 990 1000 1010 1020 LANEFTRMAR DPPRYLVIKR ESGPGIAPGP EPHGLTNKKL EEVELEPELD LDLDLEAEED 1030 1040 1050 1060 1070 1080 NLATTTLGSA LSLPVGTLNR PRGSQSLLSP SSGYMPMNQG NLGESCQESA VSGSSERCPR 1090 1100 1110 1120 1130 1140 PVSLHPMPRG CLASESSEGH VTGSEAELQE KVSMCRSRSR SRSPRPRGDS AYHSQRHSLL 1150 1160 1170 1180 1190 1200 TPVTPLSPPG LEEEDVNGYV MPDTHLKGTP SSREGTLSSV GLSSVLGTEE EDEDEEYEYM 1210 1220 1230 1240 1250 1260 NRRRRHSPPH PPRPSSLEEL GYEYMDVGSD LSASLGSTQS CPLHPVPIMP TAGTTPDEDY 1270 1280 1290 1300 1310 1320 EYMNRQRDGG GPGGDYAAMG ACPASEQGYE EMRAFQGPGH QAPHVHYARL KTLRSLEATD 1330 1340 SAFDNPDYWH SRLFPKANAQ RT

CATM prediction

The sequence of ERBB3_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           650       660     
    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 HLTMALTVIAGLVVIFMMLGGTFLYWR 7.1 -55.0° 2.4 47.9 -12.0
Model 2 HLTMALTVIAGLVVIFMMLGGTFLYWR 7.1 -54.0° 2.6 32.6 -4.7

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 658, MET, HA A, 657, MET, O 3.30Å
B, 661, GLY, HA1 A, 658, MET, O 3.03Å
A, 658, MET, HA B, 657, MET, O 3.30Å
A, 661, GLY, HA1 B, 658, MET, O 3.03Å