Macrophage scavenger receptor types I and II

UniProt data

UniProt name: MSRE_HUMAN (P21757)

Gene name: MSR1; Synonyms=SCARA1

Organism: Homo sapiens (Human).

Function: Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). Isoform III does not internalize acetylated LDL.

Subcellular location: Membrane; Single-pass type II membrane protein.

Transmembrane domains:

  1. 51-76, 26 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 451 AA

10 20 30 40 50 60 MEQWDHFHNQ QEDTDSCSES VKFDARSMTA LLPPNPKNSP SLQEKLKSFK AALIALYLLV 70 80 90 100 110 120 FAVLIPLIGI VAAQLLKWET KNCSVSSTNA NDITQSLTGK GNDSEEEMRF QEVFMEHMSN 130 140 150 160 170 180 MEKRIQHILD MEANLMDTEH FQNFSMTTDQ RFNDILLQLS TLFSSVQGHG NAIDEISKSL 190 200 210 220 230 240 ISLNTTLLDL QLNIENLNGK IQENTFKQQE EISKLEERVY NVSAEIMAMK EEQVHLEQEI 250 260 270 280 290 300 KGEVKVLNNI TNDLRLKDWE HSQTLRNITL IQGPPGPPGE KGDRGPTGES GPRGFPGPIG 310 320 330 340 350 360 PPGLKGDRGA IGFPGSRGLP GYAGRPGNSG PKGQKGEKGS GNTLTPFTKV RLVGGSGPHE 370 380 390 400 410 420 GRVEILHSGQ WGTICDDRWE VRVGQVVCRS LGYPGVQAVH KAAHFGQGTG PIWLNEVFCF 430 440 450 GRESSIEECK IRQWGTRACS HSEDAGVTCT L

CATM prediction

The sequence of MSRE_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    50        60        70        
  |    +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 SFKAALIALYLLVFAVLIALIGIVAAQLLKWE 7.2 -49.0° 1.8 45.0 -30.8
Prolines* SFKAALIALYLLVFAVLIPLIGIVAAQLLKWE          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 66, ALA, HA A, 65, ILE, O 3.42Å
B, 69, GLY, HA1 A, 66, ALA, O 3.11Å
A, 66, ALA, HA B, 65, ILE, O 3.42Å
A, 69, GLY, HA1 B, 66, ALA, O 3.11Å