Zona pellucida sperm-binding protein 3

UniProt data

UniProt name: ZP3_HUMAN (P21754)

Gene name: ZP3; Synonyms=ZP3A, ZP3B, ZPC

Organism: Homo sapiens (Human).

Function: The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.

Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P48833}; Single-pass type I membrane protein {ECO:0000255}.

Transmembrane domains:

  1. 388-408, 21 AA, Helical. {ECO:0000255}.

Sequence: 424 AA

10 20 30 40 50 60 MELSYRLFIC LLLWGSTELC YPQPLWLLQG GASHPETSVQ PVLVECQEAT LMVMVSKDLF 70 80 90 100 110 120 GTGKLIRAAD LTLGPEACEP LVSMDTEDVV RFEVGLHECG NSMQVTDDAL VYSTFLLHDP 130 140 150 160 170 180 RPVGNLSIVR TNRAEIPIEC RYPRQGNVSS QAILPTWLPF RTTVFSEEKL TFSLRLMEEN 190 200 210 220 230 240 WNAEKRSPTF HLGDAAHLQA EIHTGSHVPL RLFVDHCVAT PTPDQNASPY HTIVDFHGCL 250 260 270 280 290 300 VDGLTDASSA FKVPRPGPDT LQFTVDVFHF ANDSRNMIYI TCHLKVTLAE QDPDELNKAC 310 320 330 340 350 360 SFSKPSNSWF PVEGSADICQ CCNKGDCGTP SHSRRQPHVM SQWSRSASRN RRHVTEEADV 370 380 390 400 410 420 TVGPLIFLDR RGDHEVEQWA LPSDTSVVLL GVGLAVVVSL TLTAVILVLT RRCRTASHPV SASE

CATM prediction

The sequence of ZP3_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       390       400       41
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 TSVVLLGVGLAVVVSLTLTAVILVLTR 7.3 -44.2° 0.9 46.1 -18.1
Model 2 TSVVLLGVGLAVVVSLTLTAVILVLTR 7.3 -55.0° 2.4 48.0 -6.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 391, GLY, HA1 A, 388, VAL, O 3.39Å
B, 392, VAL, HA A, 391, GLY, O 3.44Å
A, 391, GLY, HA1 B, 388, VAL, O 3.39Å
A, 392, VAL, HA B, 391, GLY, O 3.44Å