Ephrin type-A receptor 1

UniProt data

UniProt name: EPHA1_HUMAN (P21709)

Gene name: EPHA1; Synonyms=EPH, EPHT, EPHT1

Organism: Homo sapiens (Human).

Function: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis. {ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:19118217, ECO:0000269|PubMed:20043122}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:19118217}; Single-pass type I membrane protein {ECO:0000269|PubMed:19118217}.

Transmembrane domains:

  1. 548-568, 21 AA, Helical. {ECO:0000255}.

Sequence: 976 AA

10 20 30 40 50 60 MERRWPLGLG LVLLLCAPLP PGARAKEVTL MDTSKAQGEL GWLLDPPKDG WSEQQQILNG 70 80 90 100 110 120 TPLYMYQDCP MQGRRDTDHW LRSNWIYRGE EASRVHVELQ FTVRDCKSFP GGAGPLGCKE 130 140 150 160 170 180 TFNLLYMESD QDVGIQLRRP LFQKVTTVAA DQSFTIRDLV SGSVKLNVER CSLGRLTRRG 190 200 210 220 230 240 LYLAFHNPGA CVALVSVRVF YQRCPETLNG LAQFPDTLPG PAGLVEVAGT CLPHARASPR 250 260 270 280 290 300 PSGAPRMHCS PDGEWLVPVG RCHCEPGYEE GGSGEACVAC PSGSYRMDMD TPHCLTCPQQ 310 320 330 340 350 360 STAESEGATI CTCESGHYRA PGEGPQVACT GPPSAPRNLS FSASGTQLSL RWEPPADTGG 370 380 390 400 410 420 RQDVRYSVRC SQCQGTAQDG GPCQPCGVGV HFSPGARGLT TPAVHVNGLE PYANYTFNVE 430 440 450 460 470 480 AQNGVSGLGS SGHASTSVSI SMGHAESLSG LSLRLVKKEP RQLELTWAGS RPRSPGANLT 490 500 510 520 530 540 YELHVLNQDE ERYQMVLEPR VLLTELQPDT TYIVRVRMLT PLGPGPFSPD HEFRTSPPVS 550 560 570 580 590 600 RGLTGGEIVA VIFGLLLGAA LLLGILVFRS RRAQRQRQQR QRDRATDVDR EDKLWLKPYV 610 620 630 640 650 660 DLQAYEDPAQ GALDFTRELD PAWLMVDTVI GEGEFGEVYR GTLRLPSQDC KTVAIKTLKD 670 680 690 700 710 720 TSPGGQWWNF LREATIMGQF SHPHILHLEG VVTKRKPIMI ITEFMENGAL DAFLREREDQ 730 740 750 760 770 780 LVPGQLVAML QGIASGMNYL SNHNYVHRDL AARNILVNQN LCCKVSDFGL TRLLDDFDGT 790 800 810 820 830 840 YETQGGKIPI RWTAPEAIAH RIFTTASDVW SFGIVMWEVL SFGDKPYGEM SNQEVMKSIE 850 860 870 880 890 900 DGYRLPPPVD CPAPLYELMK NCWAYDRARR PHFQKLQAHL EQLLANPHSL RTIANFDPRM 910 920 930 940 950 960 TLRLPSLSGS DGIPYRTVSE WLESIRMKRY ILHFHSAGLD TMECVLELTA EDLTQMGITL 970 PGHQKRILCS IQGFKD

CATM prediction

The sequence of EPHA1_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       550       560       57
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 GGEIVAVIFGLLLGAALLLGILVFRSR 7.2 -44.0° 1.8 59.2 -29.8
Model 2 GGEIVAVIFGLLLGAALLLGILVFRSR 7.2 -44.0° 4.9 44.0 -9.2
Model 3 GGEIVAVIFGLLLGAALLLGILVFRSR 6.4 -55.0° 2.4 47.6 -7.0

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 551, VAL, HA A, 550, ALA, O 3.10Å
B, 554, GLY, HA1 A, 551, VAL, O 3.19Å
A, 551, VAL, HA B, 550, ALA, O 3.10Å
A, 554, GLY, HA1 B, 551, VAL, O 3.19Å