Integrin alpha-X

UniProt data

UniProt name: ITAX_HUMAN (P20702)

Gene name: ITGAX; Synonyms=CD11C

Organism: Homo sapiens (Human).

Function: Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 1108-1128, 21 AA, Helical. {ECO:0000255}.

Sequence: 1163 AA

10 20 30 40 50 60 MTRTRAALLL FTALATSLGF NLDTEELTAF RVDSAGFGDS VVQYANSWVV VGAPQKITAA 70 80 90 100 110 120 NQTGGLYQCG YSTGACEPIG LQVPPEAVNM SLGLSLASTT SPSQLLACGP TVHHECGRNM 130 140 150 160 170 180 YLTGLCFLLG PTQLTQRLPV SRQECPRQEQ DIVFLIDGSG SISSRNFATM MNFVRAVISQ 190 200 210 220 230 240 FQRPSTQFSL MQFSNKFQTH FTFEEFRRSS NPLSLLASVH QLQGFTYTAT AIQNVVHRLF 250 260 270 280 290 300 HASYGARRDA AKILIVITDG KKEGDSLDYK DVIPMADAAG IIRYAIGVGL AFQNRNSWKE 310 320 330 340 350 360 LNDIASKPSQ EHIFKVEDFD ALKDIQNQLK EKIFAIEGTE TTSSSSFELE MAQEGFSAVF 370 380 390 400 410 420 TPDGPVLGAV GSFTWSGGAF LYPPNMSPTF INMSQENVDM RDSYLGYSTE LALWKGVQSL 430 440 450 460 470 480 VLGAPRYQHT GKAVIFTQVS RQWRMKAEVT GTQIGSYFGA SLCSVDVDSD GSTDLVLIGA 490 500 510 520 530 540 PHYYEQTRGG QVSVCPLPRG WRRWWCDAVL YGEQGHPWGR FGAALTVLGD VNGDKLTDVV 550 560 570 580 590 600 IGAPGEEENR GAVYLFHGVL GPSISPSHSQ RIAGSQLSSR LQYFGQALSG GQDLTQDGLV 610 620 630 640 650 660 DLAVGARGQV LLLRTRPVLW VGVSMQFIPA EIPRSAFECR EQVVSEQTLV QSNICLYIDK 670 680 690 700 710 720 RSKNLLGSRD LQSSVTLDLA LDPGRLSPRA TFQETKNRSL SRVRVLGLKA HCENFNLLLP 730 740 750 760 770 780 SCVEDSVTPI TLRLNFTLVG KPLLAFRNLR PMLAADAQRY FTASLPFEKN CGADHICQDN 790 800 810 820 830 840 LGISFSFPGL KSLLVGSNLE LNAEVMVWND GEDSYGTTIT FSHPAGLSYR YVAEGQKQGQ 850 860 870 880 890 900 LRSLHLTCDS APVGSQGTWS TSCRINHLIF RGGAQITFLA TFDVSPKAVL GDRLLLTANV 910 920 930 940 950 960 SSENNTPRTS KTTFQLELPV KYAVYTVVSS HEQFTKYLNF SESEEKESHV AMHRYQVNNL 970 980 990 1000 1010 1020 GQRDLPVSIN FWVPVELNQE AVWMDVEVSH PQNPSLRCSS EKIAPPASDF LAHIQKNPVL 1030 1040 1050 1060 1070 1080 DCSIAGCLRF RCDVPSFSVQ EELDFTLKGN LSFGWVRQIL QKKVSVVSVA EITFDTSVYS 1090 1100 1110 1120 1130 1140 QLPGQEAFMR AQTTTVLEKY KVHNPTPLIV GSSIGGLLLL ALITAVLYKV GFFKRQYKEM 1150 1160 MEEANGQIAP ENGTQTPSPP SEK

CATM prediction

The sequence of ITAX_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       1110      1120      11
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 ATALIVGSSIGGLLLLALITAVLYKVG 7.1 -30.0° 3.5 53.0 -18.7
Model 2 ATALIVGSSIGGLLLLALITAVLYKVG 6.7 -47.9° -0.0 38.0 -17.7
Model 3 ATALIVGSSIGGLLLLALITAVLYKVG 6.8 -55.0° 2.4 47.9 -9.3
Prolines* PTPLIVGSSIGGLLLLALITAVLYKVG          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1111, GLY, HA1 A, 1108, LEU, O 3.40Å
A, 1111, GLY, HA1 B, 1108, LEU, O 3.40Å