Cation-dependent mannose-6-phosphate receptor

UniProt data

UniProt name: MPRD_HUMAN (P20645)

Gene name: M6PR; Synonyms=MPR46, MPRD

Organism: Homo sapiens (Human).

Function: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.

Subcellular location: Lysosome membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 186-210, 25 AA, Helical. {ECO:0000255}.

Sequence: 277 AA

10 20 30 40 50 60 MFPFYSCWRT GLLLLLLAVA VRESWQTEEK TCDLVGEKGK ESEKELALVK RLKPLFNKSF 70 80 90 100 110 120 ESTVGQGSDT YIYIFRVCRE AGNHTSGAGL VQINKSNGKE TVVGRLNETH IFNGSNWIML 130 140 150 160 170 180 IYKGGDEYDN HCGKEQRRAV VMISCNRHTL ADNFNPVSEE RGKVQDCFYL FEMDSSLACS 190 200 210 220 230 240 PEISHLSVGS ILLVTFASLV AVYVVGGFLY QRLVVGAKGM EQFPHLAFWQ DLGNLVADGC 250 260 270 DFVCRSKPRN VPAAYRGVGD DQLGEESEER DDHLLPM

CATM prediction

The sequence of MPRD_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         190       200       210 
  +    |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 ISHLSVGSILLVTFASLVAVYVVGGFLYQRL 7.2 -55.1° 0.9 50.0 -18.0

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 206, GLY, HA1 A, 203, TYR, O 3.27Å
B, 207, GLY, HA2 A, 206, GLY, O 3.46Å
A, 206, GLY, HA1 B, 203, TYR, O 3.27Å
A, 207, GLY, HA2 B, 206, GLY, O 3.46Å