Atrial natriuretic peptide receptor 2

UniProt data

UniProt name: ANPRB_HUMAN (P20594)

Gene name: NPR2; Synonyms=ANPRB

Organism: Homo sapiens (Human).

Function: Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth. {ECO:0000269|PubMed:15146390, ECO:0000269|PubMed:1672777, ECO:0000269|PubMed:24001744, ECO:0000269|PubMed:24471569, ECO:0000269|PubMed:26980729}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:24001744, ECO:0000269|PubMed:26980729}; Single-pass type I membrane protein {ECO:0000305|PubMed:26980729}.

Transmembrane domains:

  1. 459-478, 20 AA, Helical. {ECO:0000255}.

Sequence: 1047 AA

10 20 30 40 50 60 MALPSLLLLV AALAGGVRPP GARNLTLAVV LPEHNLSYAW AWPRVGPAVA LAVEALGRAL 70 80 90 100 110 120 PVDLRFVSSE LEGACSEYLA PLSAVDLKLY HDPDLLLGPG CVYPAASVAR FASHWRLPLL 130 140 150 160 170 180 TAGAVASGFS AKNDHYRTLV RTGPSAPKLG EFVVTLHGHF NWTARAALLY LDARTDDRPH 190 200 210 220 230 240 YFTIEGVFEA LQGSNLSVQH QVYAREPGGP EQATHFIRAN GRIVYICGPL EMLHEILLQA 250 260 270 280 290 300 QRENLTNGDY VFFYLDVFGE SLRAGPTRAT GRPWQDNRTR EQAQALREAF QTVLVITYRE 310 320 330 340 350 360 PPNPEYQEFQ NRLLIRARED FGVELGPSLM NLIAGCFYDG ILLYAEVLNE TIQEGGTRED 370 380 390 400 410 420 GLRIVEKMQG RRYHGVTGLV VMDKNNDRET DFVLWAMGDL DSGDFQPAAH YSGAEKQIWW 430 440 450 460 470 480 TGRPIPWVKG APPSDNPPCA FDLDDPSCDK TPLSTLAIVA LGTGITFIMF GVSSFLIFRK 490 500 510 520 530 540 LMLEKELASM LWRIRWEELQ FGNSERYHKG AGSRLTLSLR GSSYGSLMTA HGKYQIFANT 550 560 570 580 590 600 GHFKGNVVAI KHVNKKRIEL TRQVLFELKH MRDVQFNHLT RFIGACIDPP NICIVTEYCP 610 620 630 640 650 660 RGSLQDILEN DSINLDWMFR YSLINDLVKG MAFLHNSIIS SHGSLKSSNC VVDSRFVLKI 670 680 690 700 710 720 TDYGLASFRS TAEPDDSHAL YAKKLWTAPE LLSGNPLPTT GMQKADVYSF GIILQEIALR 730 740 750 760 770 780 SGPFYLEGLD LSPKEIVQKV RNGQRPYFRP SIDRTQLNEE LVLLMERCWA QDPAERPDFG 790 800 810 820 830 840 QIKGFIRRFN KEGGTSILDN LLLRMEQYAN NLEKLVEERT QAYLEEKRKA EALLYQILPH 850 860 870 880 890 900 SVAEQLKRGE TVQAEAFDSV TIYFSDIVGF TALSAESTPM QVVTLLNDLY TCFDAIIDNF 910 920 930 940 950 960 DVYKVETIGD AYMVVSGLPG RNGQRHAPEI ARMALALLDA VSSFRIRHRP HDQLRLRIGV 970 980 990 1000 1010 1020 HTGPVCAGVV GLKMPRYCLF GDTVNTASRM ESNGQALKIH VSSTTKDALD ELGCFQLELR 1030 1040 GDVEMKGKGK MRTYWLLGER KGPPGLL

CATM prediction

The sequence of ANPRB_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      460       470       48
    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 LAIVALGTGITFIMFGVSSFLIFRKL 7.2 -54.4° 3.6 48.7 -34.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 468, ILE, HA A, 467, PHE, O 3.15Å
B, 471, GLY, HA1 A, 468, ILE, O 3.38Å
A, 468, ILE, HA B, 467, PHE, O 3.15Å
A, 471, GLY, HA1 B, 468, ILE, O 3.38Å