Tumor necrosis factor receptor superfamily member 1B

UniProt data

UniProt name: TNR1B_HUMAN (P20333)

Gene name: TNFRSF1B; Synonyms=TNFBR, TNFR2

Organism: Homo sapiens (Human).

Function: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. {ECO:0000269|PubMed:12370298}.

Subcellular location: Tumor necrosis factor-binding protein 2: Secreted.

Transmembrane domains:

  1. 258-287, 30 AA, Helical. {ECO:0000255}.

Sequence: 461 AA

10 20 30 40 50 60 MAPVAVWAAL AVGLELWAAA HALPAQVAFT PYAPEPGSTC RLREYYDQTA QMCCSKCSPG 70 80 90 100 110 120 QHAKVFCTKT SDTVCDSCED STYTQLWNWV PECLSCGSRC SSDQVETQAC TREQNRICTC 130 140 150 160 170 180 RPGWYCALSK QEGCRLCAPL RKCRPGFGVA RPGTETSDVV CKPCAPGTFS NTTSSTDICR 190 200 210 220 230 240 PHQICNVVAI PGNASMDAVC TSTSPTRSMA PGAVHLPQPV STRSQHTQPT PEPSTAPSTS 250 260 270 280 290 300 FLLPMGPSPP AEGSTGDFAL PVGLIVGVTA LGLLIIGVVN CVIMTQVKKK PLCLQREAKV 310 320 330 340 350 360 PHLPADKARG TQGPEQQHLL ITAPSSSSSS LESSASALDR RAPTRNQPQA PGVEASGAGE 370 380 390 400 410 420 ARASTGSSDS SPGGHGTQVN VTCIVNVCSS SDHSSQCSSQ ASSTMGDTDS SPSESPKDEQ 430 440 450 460 VPFSKEECAF RSQLETPETL LGSTEEKPLP LGVPDAGMKP S

CATM prediction

The sequence of TNR1B_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       260       270       280       2
+    |    +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 TGDFALAVGLIVGVTALGLLIIGVVNCVIMTQVKKK 7.3 -50.6° 2.4 45.1 -27.6
Model 2 TGDFALAVGLIVGVTALGLLIIGVVNCVIMTQVKKK 7.2 -30.0° 3.4 53.1 -20.2
Model 3 TGDFALAVGLIVGVTALGLLIIGVVNCVIMTQVKKK 7.1 -42.9° 3.4 50.1 -18.5
Model 4 TGDFALAVGLIVGVTALGLLIIGVVNCVIMTQVKKK 7.0 +54.2° 3.3 80.1 -5.5
Prolines* TGDFALPVGLIVGVTALGLLIIGVVNCVIMTQVKKK          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 274, LEU, HA A, 273, LEU, O 3.47Å
B, 277, GLY, HA1 A, 274, LEU, O 3.23Å
A, 274, LEU, HA B, 273, LEU, O 3.47Å
A, 277, GLY, HA1 B, 274, LEU, O 3.23Å