B-cell receptor CD22

UniProt data

UniProt name: CD22_HUMAN (P20273)

Gene name: CD22; Synonyms=SIGLEC2

Organism: Homo sapiens (Human).

Function: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Subcellular location: Cell membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 688-706, 19 AA, Helical. {ECO:0000255}.

Sequence: 847 AA

10 20 30 40 50 60 MHLLGPWLLL LVLEYLAFSD SSKWVFEHPE TLYAWEGACV WIPCTYRALD GDLESFILFH 70 80 90 100 110 120 NPEYNKNTSK FDGTRLYEST KDGKVPSEQK RVQFLGDKNK NCTLSIHPVH LNDSGQLGLR 130 140 150 160 170 180 MESKTEKWME RIHLNVSERP FPPHIQLPPE IQESQEVTLT CLLNFSCYGY PIQLQWLLEG 190 200 210 220 230 240 VPMRQAAVTS TSLTIKSVFT RSELKFSPQW SHHGKIVTCQ LQDADGKFLS NDTVQLNVKH 250 260 270 280 290 300 TPKLEIKVTP SDAIVREGDS VTMTCEVSSS NPEYTTVSWL KDGTSLKKQN TFTLNLREVT 310 320 330 340 350 360 KDQSGKYCCQ VSNDVGPGRS EEVFLQVQYA PEPSTVQILH SPAVEGSQVE FLCMSLANPL 370 380 390 400 410 420 PTNYTWYHNG KEMQGRTEEK VHIPKILPWH AGTYSCVAEN ILGTGQRGPG AELDVQYPPK 430 440 450 460 470 480 KVTTVIQNPM PIREGDTVTL SCNYNSSNPS VTRYEWKPHG AWEEPSLGVL KIQNVGWDNT 490 500 510 520 530 540 TIACAACNSW CSWASPVALN VQYAPRDVRV RKIKPLSEIH SGNSVSLQCD FSSSHPKEVQ 550 560 570 580 590 600 FFWEKNGRLL GKESQLNFDS ISPEDAGSYS CWVNNSIGQT ASKAWTLEVL YAPRRLRVSM 610 620 630 640 650 660 SPGDQVMEGK SATLTCESDA NPPVSHYTWF DWNNQSLPYH SQKLRLEPVK VQHSGAYWCQ 670 680 690 700 710 720 GTNSVGKGRS PLSTLTVYYS PETIGRRVAV GLGSCLAILI LAICGLKLQR RWKRTQSQQG 730 740 750 760 770 780 LQENSSGQSF FVRNKKVRRA PLSEGPHSLG CYNPMMEDGI SYTTLRFPEM NIPRTGDAES 790 800 810 820 830 840 SEMQRPPPDC DDTVTYSALH KRQVGDYENV IPDFPEDEGI HYSELIQFGV GERPQAQENV DYVILKH

CATM prediction

The sequence of CD22_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       690       700       
+    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 GRRVAVGLGSCLAILILAICGLKLQ 7.1 -50.0° 2.9 47.0 -10.8
Model 2 GRRVAVGLGSCLAILILAICGLKLQ 7.3 -42.9° 3.4 50.1 -3.8

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 691, GLY, HA1 A, 688, VAL, O 3.07Å
A, 691, GLY, HA1 B, 688, VAL, O 3.07Å