Complement receptor type 2

UniProt data

UniProt name: CR2_HUMAN (P20023)

Gene name: CR2; Synonyms=C3DR

Organism: Homo sapiens (Human).

Function: (Microbial infection) Acts as a receptor for Epstein- Barr virus. {ECO:0000269|PubMed:2460635}.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 972-999, 28 AA, Helical. {ECO:0000255}.

Sequence: 1033 AA

10 20 30 40 50 60 MGAAGLLGVF LALVAPGVLG ISCGSPPPIL NGRISYYSTP IAVGTVIRYS CSGTFRLIGE 70 80 90 100 110 120 KSLLCITKDK VDGTWDKPAP KCEYFNKYSS CPEPIVPGGY KIRGSTPYRH GDSVTFACKT 130 140 150 160 170 180 NFSMNGNKSV WCQANNMWGP TRLPTCVSVF PLECPALPMI HNGHHTSENV GSIAPGLSVT 190 200 210 220 230 240 YSCESGYLLV GEKIINCLSS GKWSAVPPTC EEARCKSLGR FPNGKVKEPP ILRVGVTANF 250 260 270 280 290 300 FCDEGYRLQG PPSSRCVIAG QGVAWTKMPV CEEIFCPSPP PILNGRHIGN SLANVSYGSI 310 320 330 340 350 360 VTYTCDPDPE EGVNFILIGE STLRCTVDSQ KTGTWSGPAP RCELSTSAVQ CPHPQILRGR 370 380 390 400 410 420 MVSGQKDRYT YNDTVIFACM FGFTLKGSKQ IRCNAQGTWE PSAPVCEKEC QAPPNILNGQ 430 440 450 460 470 480 KEDRHMVRFD PGTSIKYSCN PGYVLVGEES IQCTSEGVWT PPVPQCKVAA CEATGRQLLT 490 500 510 520 530 540 KPQHQFVRPD VNSSCGEGYK LSGSVYQECQ GTIPWFMEIR LCKEITCPPP PVIYNGAHTG 550 560 570 580 590 600 SSLEDFPYGT TVTYTCNPGP ERGVEFSLIG ESTIRCTSND QERGTWSGPA PLCKLSLLAV 610 620 630 640 650 660 QCSHVHIANG YKISGKEAPY FYNDTVTFKC YSGFTLKGSS QIRCKADNTW DPEIPVCEKE 670 680 690 700 710 720 TCQHVRQSLQ ELPAGSRVEL VNTSCQDGYQ LTGHAYQMCQ DAENGIWFKK IPLCKVIHCH 730 740 750 760 770 780 PPPVIVNGKH TGMMAENFLY GNEVSYECDQ GFYLLGEKKL QCRSDSKGHG SWSGPSPQCL 790 800 810 820 830 840 RSPPVTRCPN PEVKHGYKLN KTHSAYSHND IVYVDCNPGF IMNGSRVIRC HTDNTWVPGV 850 860 870 880 890 900 PTCIKKAFIG CPPPPKTPNG NHTGGNIARF SPGMSILYSC DQGYLLVGEA LLLCTHEGTW 910 920 930 940 950 960 SQPAPHCKEV NCSSPADMDG IQKGLEPRKM YQYGAVVTLE CEDGYMLEGS PQSQCQSDHQ 970 980 990 1000 1010 1020 WNPPLAVCRS RSLAPVLCGI AAGLILLTFL IVITLYVISK HRARNYYTDT SQKEAFHLEA 1030 REVYSVDPYN PAS

CATM prediction

The sequence of CR2_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   970       980       990       100
 |    +    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 RSRSLAAVLCGIAAGLILLTFLIVITLYVISKHR 6.8 -51.8° 1.3 57.2 -28.0
Model 2 RSRSLAAVLCGIAAGLILLTFLIVITLYVISKHR 7.2 -36.2° 2.4 59.1 -21.3
Prolines* RSRSLAPVLCGIAAGLILLTFLIVITLYVISKHR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 976, VAL, HA A, 975, ALA, O 3.08Å
B, 979, GLY, HA1 A, 976, VAL, O 2.80Å
B, 980, ILE, HA A, 979, GLY, O 3.41Å
A, 976, VAL, HA B, 975, ALA, O 3.08Å
A, 979, GLY, HA1 B, 976, VAL, O 2.80Å
A, 980, ILE, HA B, 979, GLY, O 3.41Å