Vascular cell adhesion protein 1

UniProt data

UniProt name: VCAM1_HUMAN (P19320)

Gene name: VCAM1; Synonyms=L1CAM

Organism: Homo sapiens (Human).

Function: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 699-720, 22 AA, Helical. {ECO:0000255}.

Sequence: 739 AA

10 20 30 40 50 60 MPGKMVVILG ASNILWIMFA ASQAFKIETT PESRYLAQIG DSVSLTCSTT GCESPFFSWR 70 80 90 100 110 120 TQIDSPLNGK VTNEGTTSTL TMNPVSFGNE HSYLCTATCE SRKLEKGIQV EIYSFPKDPE 130 140 150 160 170 180 IHLSGPLEAG KPITVKCSVA DVYPFDRLEI DLLKGDHLMK SQEFLEDADR KSLETKSLEV 190 200 210 220 230 240 TFTPVIEDIG KVLVCRAKLH IDEMDSVPTV RQAVKELQVY ISPKNTVISV NPSTKLQEGG 250 260 270 280 290 300 SVTMTCSSEG LPAPEIFWSK KLDNGNLQHL SGNATLTLIA MRMEDSGIYV CEGVNLIGKN 310 320 330 340 350 360 RKEVELIVQE KPFTVEISPG PRIAAQIGDS VMLTCSVMGC ESPSFSWRTQ IDSPLSGKVR 370 380 390 400 410 420 SEGTNSTLTL SPVSFENEHS YLCTVTCGHK KLEKGIQVEL YSFPRDPEIE MSGGLVNGSS 430 440 450 460 470 480 VTVSCKVPSV YPLDRLEIEL LKGETILENI EFLEDTDMKS LENKSLEMTF IPTIEDTGKA 490 500 510 520 530 540 LVCQAKLHID DMEFEPKQRQ STQTLYVNVA PRDTTVLVSP SSILEEGSSV NMTCLSQGFP 550 560 570 580 590 600 APKILWSRQL PNGELQPLSE NATLTLISTK MEDSGVYLCE GINQAGRSRK EVELIIQVTP 610 620 630 640 650 660 KDIKLTAFPS ESVKEGDTVI ISCTCGNVPE TWIILKKKAE TGDTVLKSID GAYTIRKAQL 670 680 690 700 710 720 KDAGVYECES KNKVGSQLRS LTLDVQGREN NKDYFSPELL VLYFASSLII PAIGMIIYFA 730 RKANMKGSYS LVEAQKSKV

CATM prediction

The sequence of VCAM1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      700       710       720 
    |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 SAELLVLYFASSLIIAAIGMIIYFARKA 7.0 -52.9° 2.0 44.9 -13.8
Prolines* SPELLVLYFASSLIIPAIGMIIYFARKA          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 711, ALA, HA A, 710, ILE, O 3.42Å
B, 714, GLY, HA1 A, 711, ALA, O 3.03Å
A, 703, TYR, HH B, 703, TYR, OH 2.10Å
A, 711, ALA, HA B, 710, ILE, O 3.42Å
A, 714, GLY, HA1 B, 711, ALA, O 3.03Å