Cyclic AMP-dependent transcription factor ATF-6 alpha

UniProt data

UniProt name: ATF6A_HUMAN (P18850)

Gene name: ATF6

Organism: Homo sapiens (Human).

Function: Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'- ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina. {ECO:0000269|PubMed:10564271, ECO:0000269|PubMed:11158310, ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:26029869}.

Subcellular location: Processed cyclic AMP-dependent transcription factor ATF-6 alpha: Nucleus. Note=Under ER stress the cleaved N- terminal cytoplasmic domain translocates into the nucleus. THBS4 promotes its nuclear shuttling.

Transmembrane domains:

  1. 378-398, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 670 AA

10 20 30 40 50 60 MGEPAGVAGT MESPFSPGLF HRLDEDWDSA LFAELGYFTD TDELQLEAAN ETYENNFDNL 70 80 90 100 110 120 DFDLDLMPWE SDIWDINNQI CTVKDIKAEP QPLSPASSSY SVSSPRSVDS YSSTQHVPEE 130 140 150 160 170 180 LDLSSSSQMS PLSLYGENSN SLSSAEPLKE DKPVTGPRNK TENGLTPKKK IQVNSKPSIQ 190 200 210 220 230 240 PKPLLLPAAP KTQTNSSVPA KTIIIQTVPT LMPLAKQQPI ISLQPAPTKG QTVLLSQPTV 250 260 270 280 290 300 VQLQAPGVLP SAQPVLAVAG GVTQLPNHVV NVVPAPSANS PVNGKLSVTK PVLQSTMRNV 310 320 330 340 350 360 GSDIAVLRRQ QRMIKNRESA CQSRKKKKEY MLGLEARLKA ALSENEQLKK ENGTLKRQLD 370 380 390 400 410 420 EVVSENQRLK VPSPKRRVVC VMIVLAFIIL NYGPMSMLEQ DSRRMNPSVS PANQRRHLLG 430 440 450 460 470 480 FSAKEAQDTS DGIIQKNSYR YDHSVSNDKA LMVLTEEPLL YIPPPPCQPL INTTESLRLN 490 500 510 520 530 540 HELRGWVHRH EVERTKSRRM TNNQQKTRIL QGALEQGSNS QLMAVQYTET TSSISRNSGS 550 560 570 580 590 600 ELQVYYASPR SYQDFFEAIR RRGDTFYVVS FRRDHLLLPA TTHNKTTRPK MSIVLPAINI 610 620 630 640 650 660 NENVINGQDY EVMMQIDCQV MDTRILHIKS SSVPPYLRDQ QRNQTNTFFG SPPAATEATH VVSTIPESLQ

CATM prediction

The sequence of ATF6A_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       380       390       40
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 KRRVVCVMIVLAFIILNYGAMSMLEQD 7.0 -47.4° 1.3 45.0 -3.0
Prolines* KRRVVCVMIVLAFIILNYGPMSMLEQD          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 390, LEU, HA A, 389, ILE, O 3.37Å
B, 393, GLY, HA1 A, 390, LEU, O 3.04Å
B, 394, ALA, HA A, 393, GLY, O 3.40Å
A, 390, LEU, HA B, 389, ILE, O 3.37Å
A, 393, GLY, HA1 B, 390, LEU, O 3.04Å
A, 394, ALA, HA B, 393, GLY, O 3.40Å