UniProt data
UniProt name: LAG3_HUMAN (P18627)
Gene name: LAG3; Synonyms=FDC
Organism: Homo sapiens (Human).
Function: Involved in lymphocyte activation. Binds to HLA class-II antigens.
Subcellular location: Membrane; Single-pass type I membrane protein.
Transmembrane domains:
- 451-471, 21 AA, Helical. {ECO:0000255}.
Sequence: 525 AA
10 20 30 40 50 60
MWEAQFLGLL FLQPLWVAPV KPLQPGAEVP VVWAQEGAPA QLPCSPTIPL QDLSLLRRAG
70 80 90 100 110 120
VTWQHQPDSG PPAAAPGHPL APGPHPAAPS SWGPRPRRYT VLSVGPGGLR SGRLPLQPRV
130 140 150 160 170 180
QLDERGRQRG DFSLWLRPAR RADAGEYRAA VHLRDRALSC RLRLRLGQAS MTASPPGSLR
190 200 210 220 230 240
ASDWVILNCS FSRPDRPASV HWFRNRGQGR VPVRESPHHH LAESFLFLPQ VSPMDSGPWG
250 260 270 280 290 300
CILTYRDGFN VSIMYNLTVL GLEPPTPLTV YAGAGSRVGL PCRLPAGVGT RSFLTAKWTP
310 320 330 340 350 360
PGGGPDLLVT GDNGDFTLRL EDVSQAQAGT YTCHIHLQEQ QLNATVTLAI ITVTPKSFGS
370 380 390 400 410 420
PGSLGKLLCE VTPVSGQERF VWSSLDTPSQ RSFSGPWLEA QEAQLLSQPW QCQLYQGERL
430 440 450 460 470 480
LGAAVYFTEL SSPGAQRSGR APGALPAGHL LLFLILGVLS LLLLVTGAFG FHLWRRQWRP
490 500 510 520
RRFSALEQGI HPPQAQSKIE ELEQEPEPEP EPEPEPEPEP EPEQL
CATM prediction
The sequence of LAG3_HUMAN returned 1 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 450 460 470 | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | GHLLLFLILGVLSLLLLVTGAFGFHLW | 6.8 | -55.2° | 1.5 | 45.3 | -26.8 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 464, LEU, HA | A, 463, LEU, O | 3.19Å |
| B, 467, GLY, HA1 | A, 464, LEU, O | 2.62Å |
| B, 468, ALA, HA | A, 467, GLY, O | 3.25Å |
| A, 464, LEU, HA | B, 463, LEU, O | 3.19Å |
| A, 467, GLY, HA1 | B, 464, LEU, O | 2.62Å |
| A, 468, ALA, HA | B, 467, GLY, O | 3.25Å |