Integrin beta-6

UniProt data

UniProt name: ITB6_HUMAN (P18564)

Gene name: ITGB6

Organism: Homo sapiens (Human).

Function: (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 (PubMed:9426447, PubMed:15194773). Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex virus-1/HHV-1 (PubMed:24367260). {ECO:0000269|PubMed:15194773, ECO:0000269|PubMed:24367260, ECO:0000269|PubMed:9426447}.

Subcellular location: Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion {ECO:0000269|PubMed:17158881}.

Transmembrane domains:

  1. 710-730, 21 AA, Helical. {ECO:0000255}.

Sequence: 788 AA

10 20 30 40 50 60 MGIELLCLFF LFLGRNDHVQ GGCALGGAET CEDCLLIGPQ CAWCAQENFT HPSGVGERCD 70 80 90 100 110 120 TPANLLAKGC QLNFIENPVS QVEILKNKPL SVGRQKNSSD IVQIAPQSLI LKLRPGGAQT 130 140 150 160 170 180 LQVHVRQTED YPVDLYYLMD LSASMDDDLN TIKELGSRLS KEMSKLTSNF RLGFGSFVEK 190 200 210 220 230 240 PVSPFVKTTP EEIANPCSSI PYFCLPTFGF KHILPLTNDA ERFNEIVKNQ KISANIDTPE 250 260 270 280 290 300 GGFDAIMQAA VCKEKIGWRN DSLHLLVFVS DADSHFGMDS KLAGIVIPND GLCHLDSKNE 310 320 330 340 350 360 YSMSTVLEYP TIGQLIDKLV QNNVLLIFAV TQEQVHLYEN YAKLIPGATV GLLQKDSGNI 370 380 390 400 410 420 LQLIISAYEE LRSEVELEVL GDTEGLNLSF TAICNNGTLF QHQKKCSHMK VGDTASFSVT 430 440 450 460 470 480 VNIPHCERRS RHIIIKPVGL GDALELLVSP ECNCDCQKEV EVNSSKCHHG NGSFQCGVCA 490 500 510 520 530 540 CHPGHMGPRC ECGEDMLSTD SCKEAPDHPS CSGRGDCYCG QCICHLSPYG NIYGPYCQCD 550 560 570 580 590 600 NFSCVRHKGL LCGGNGDCDC GECVCRSGWT GEYCNCTTST DSCVSEDGVL CSGRGDCVCG 610 620 630 640 650 660 KCVCTNPGAS GPTCERCPTC GDPCNSKRSC IECHLSAAGQ AREECVDKCK LAGATISEEE 670 680 690 700 710 720 DFSKDGSVSC SLQGENECLI TFLITTDNEG KTIIHSINEK DCPKPPNIPM IMLGVSLAIL 730 740 750 760 770 780 LIGVVLLCIW KLLVSFHDRK EVAKFEAERS KAKWQTGTNP LYRGSTSTFK NVTYKHREKQ KVDLSTDC

CATM prediction

The sequence of ITB6_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     710       720       730 
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 NIAMIMLGVSLAILLIGVVLLCIWKLL 7.1 -47.0° 2.2 45.0 -27.6
Prolines* NIPMIMLGVSLAILLIGVVLLCIWKLL          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 711, ILE, HA A, 710, MET, O 3.20Å
B, 714, GLY, HA1 A, 711, ILE, O 3.02Å
A, 711, ILE, HA B, 710, MET, O 3.20Å
A, 714, GLY, HA1 B, 711, ILE, O 3.02Å