Complement receptor type 1

UniProt data

UniProt name: CR1_HUMAN (P17927)

Gene name: CR1; Synonyms=C3BR

Organism: Homo sapiens (Human).

Function: (Microbial infection) Acts as a receptor for Epstein- Barr virus. {ECO:0000269|PubMed:23416052}.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 1972-1996, 25 AA, Helical. {ECO:0000255}.

Sequence: 2039 AA

10 20 30 40 50 60 MGASSPRSPE PVGPPAPGLP FCCGGSLLAV VVLLALPVAW GQCNAPEWLP FARPTNLTDE 70 80 90 100 110 120 FEFPIGTYLN YECRPGYSGR PFSIICLKNS VWTGAKDRCR RKSCRNPPDP VNGMVHVIKG 130 140 150 160 170 180 IQFGSQIKYS CTKGYRLIGS SSATCIISGD TVIWDNETPI CDRIPCGLPP TITNGDFIST 190 200 210 220 230 240 NRENFHYGSV VTYRCNPGSG GRKVFELVGE PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP 250 260 270 280 290 300 PNVENGILVS DNRSLFSLNE VVEFRCQPGF VMKGPRRVKC QALNKWEPEL PSCSRVCQPP 310 320 330 340 350 360 PDVLHAERTQ RDKDNFSPGQ EVFYSCEPGY DLRGAASMRC TPQGDWSPAA PTCEVKSCDD 370 380 390 400 410 420 FMGQLLNGRV LFPVNLQLGA KVDFVCDEGF QLKGSSASYC VLAGMESLWN SSVPVCEQIF 430 440 450 460 470 480 CPSPPVIPNG RHTGKPLEVF PFGKTVNYTC DPHPDRGTSF DLIGESTIRC TSDPQGNGVW 490 500 510 520 530 540 SSPAPRCGIL GHCQAPDHFL FAKLKTQTNA SDFPIGTSLK YECRPEYYGR PFSITCLDNL 550 560 570 580 590 600 VWSSPKDVCK RKSCKTPPDP VNGMVHVITD IQVGSRINYS CTTGHRLIGH SSAECILSGN 610 620 630 640 650 660 AAHWSTKPPI CQRIPCGLPP TIANGDFIST NRENFHYGSV VTYRCNPGSG GRKVFELVGE 670 680 690 700 710 720 PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP PNVENGILVS DNRSLFSLNE VVEFRCQPGF 730 740 750 760 770 780 VMKGPRRVKC QALNKWEPEL PSCSRVCQPP PDVLHAERTQ RDKDNFSPGQ EVFYSCEPGY 790 800 810 820 830 840 DLRGAASMRC TPQGDWSPAA PTCEVKSCDD FMGQLLNGRV LFPVNLQLGA KVDFVCDEGF 850 860 870 880 890 900 QLKGSSASYC VLAGMESLWN SSVPVCEQIF CPSPPVIPNG RHTGKPLEVF PFGKAVNYTC 910 920 930 940 950 960 DPHPDRGTSF DLIGESTIRC TSDPQGNGVW SSPAPRCGIL GHCQAPDHFL FAKLKTQTNA 970 980 990 1000 1010 1020 SDFPIGTSLK YECRPEYYGR PFSITCLDNL VWSSPKDVCK RKSCKTPPDP VNGMVHVITD 1030 1040 1050 1060 1070 1080 IQVGSRINYS CTTGHRLIGH SSAECILSGN TAHWSTKPPI CQRIPCGLPP TIANGDFIST 1090 1100 1110 1120 1130 1140 NRENFHYGSV VTYRCNLGSR GRKVFELVGE PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP 1150 1160 1170 1180 1190 1200 PNVENGILVS DNRSLFSLNE VVEFRCQPGF VMKGPRRVKC QALNKWEPEL PSCSRVCQPP 1210 1220 1230 1240 1250 1260 PEILHGEHTP SHQDNFSPGQ EVFYSCEPGY DLRGAASLHC TPQGDWSPEA PRCAVKSCDD 1270 1280 1290 1300 1310 1320 FLGQLPHGRV LFPLNLQLGA KVSFVCDEGF RLKGSSVSHC VLVGMRSLWN NSVPVCEHIF 1330 1340 1350 1360 1370 1380 CPNPPAILNG RHTGTPSGDI PYGKEISYTC DPHPDRGMTF NLIGESTIRC TSDPHGNGVW 1390 1400 1410 1420 1430 1440 SSPAPRCELS VRAGHCKTPE QFPFASPTIP INDFEFPVGT SLNYECRPGY FGKMFSISCL 1450 1460 1470 1480 1490 1500 ENLVWSSVED NCRRKSCGPP PEPFNGMVHI NTDTQFGSTV NYSCNEGFRL IGSPSTTCLV 1510 1520 1530 1540 1550 1560 SGNNVTWDKK APICEIISCE PPPTISNGDF YSNNRTSFHN GTVVTYQCHT GPDGEQLFEL 1570 1580 1590 1600 1610 1620 VGERSIYCTS KDDQVGVWSS PPPRCISTNK CTAPEVENAI RVPGNRSFFS LTEIIRFRCQ 1630 1640 1650 1660 1670 1680 PGFVMVGSHT VQCQTNGRWG PKLPHCSRVC QPPPEILHGE HTLSHQDNFS PGQEVFYSCE 1690 1700 1710 1720 1730 1740 PSYDLRGAAS LHCTPQGDWS PEAPRCTVKS CDDFLGQLPH GRVLLPLNLQ LGAKVSFVCD 1750 1760 1770 1780 1790 1800 EGFRLKGRSA SHCVLAGMKA LWNSSVPVCE QIFCPNPPAI LNGRHTGTPF GDIPYGKEIS 1810 1820 1830 1840 1850 1860 YACDTHPDRG MTFNLIGESS IRCTSDPQGN GVWSSPAPRC ELSVPAACPH PPKIQNGHYI 1870 1880 1890 1900 1910 1920 GGHVSLYLPG MTISYICDPG YLLVGKGFIF CTDQGIWSQL DHYCKEVNCS FPLFMNGISK 1930 1940 1950 1960 1970 1980 ELEMKKVYHY GDYVTLKCED GYTLEGSPWS QCQADDRWDP PLAKCTSRTH DALIVGTLSG 1990 2000 2010 2020 2030 TIFFILLIIF LSWIILKHRK GNNAHENPKE VAIHLHSQGG SSVHPRTLQT NEENSRVLP

CATM prediction

The sequence of CR1_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   1970      1980      1990      
 |    +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 THDALIVGTLSGTIFFILLIIFLSWIILKHR 6.9 -46.0° 2.7 47.1 -33.6
Model 2 THDALIVGTLSGTIFFILLIIFLSWIILKHR 7.2 -55.0° 2.4 48.1 -19.5
Model 3 THDALIVGTLSGTIFFILLIIFLSWIILKHR 7.2 -30.2° 5.7 37.0 -13.2
Model 4 THDALIVGTLSGTIFFILLIIFLSWIILKHR 7.4 -53.7° 3.6 49.2 -11.7

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1973, LEU, HA A, 1972, ALA, O 2.93Å
B, 1976, GLY, HA1 A, 1973, LEU, O 2.82Å
B, 1977, THR, HA A, 1976, GLY, O 3.27Å
A, 1973, LEU, HA B, 1972, ALA, O 2.93Å
A, 1976, GLY, HA1 B, 1973, LEU, O 2.82Å
A, 1977, THR, HA B, 1976, GLY, O 3.27Å