Endoglin

UniProt data

UniProt name: EGLN_HUMAN (P17813)

Gene name: ENG; Synonyms=END

Organism: Homo sapiens (Human).

Function: Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF- beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGF-beta1 signaling through SMAD3. {ECO:0000269|PubMed:21737454, ECO:0000269|PubMed:23300529}.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 587-611, 25 AA, Helical. {ECO:0000255}.

Sequence: 658 AA

10 20 30 40 50 60 MDRGTLPLAV ALLLASCSLS PTSLAETVHC DLQPVGPERG EVTYTTSQVS KGCVAQAPNA 70 80 90 100 110 120 ILEVHVLFLE FPTGPSQLEL TLQASKQNGT WPREVLLVLS VNSSVFLHLQ ALGIPLHLAY 130 140 150 160 170 180 NSSLVTFQEP PGVNTTELPS FPKTQILEWA AERGPITSAA ELNDPQSILL RLGQAQGSLS 190 200 210 220 230 240 FCMLEASQDM GRTLEWRPRT PALVRGCHLE GVAGHKEAHI LRVLPGHSAG PRTVTVKVEL 250 260 270 280 290 300 SCAPGDLDAV LILQGPPYVS WLIDANHNMQ IWTTGEYSFK IFPEKNIRGF KLPDTPQGLL 310 320 330 340 350 360 GEARMLNASI VASFVELPLA SIVSLHASSC GGRLQTSPAP IQTTPPKDTC SPELLMSLIQ 370 380 390 400 410 420 TKCADDAMTL VLKKELVAHL KCTITGLTFW DPSCEAEDRG DKFVLRSAYS SCGMQVSASM 430 440 450 460 470 480 ISNEAVVNIL SSSSPQRKKV HCLNMDSLSF QLGLYLSPHF LQASNTIEPG QQSFVQVRVS 490 500 510 520 530 540 PSVSEFLLQL DSCHLDLGPE GGTVELIQGR AAKGNCVSLL SPSPEGDPRF SFLLHFYTVP 550 560 570 580 590 600 IPKTGTLSCT VALRPKTGSQ DQEVHRTVFM RLNIISPDLS GCTSKGLVLP AVLGITFGAF 610 620 630 640 650 LIGALLTAAL WYIYSHTRSP SKREPVVAVA APASSESSST NHSIGSTQST PCSTSSMA

CATM prediction

The sequence of EGLN_HUMAN returned 5 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        590       600       610  
 +    |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 SKGLVLAAVLGITFGAFLIGALLTAALWYIY 7.3 -48.0° 3.3 34.3 -26.9
Model 2 SKGLVLAAVLGITFGAFLIGALLTAALWYIY 7.2 -55.2° 2.4 48.2 -24.1
Model 3 SKGLVLAAVLGITFGAFLIGALLTAALWYIY 6.8 -55.0° 4.2 38.1 -18.8
Model 4 SKGLVLAAVLGITFGAFLIGALLTAALWYIY 7.4 -49.0° 3.9 38.2 -13.1
Model 5 SKGLVLAAVLGITFGAFLIGALLTAALWYIY 7.2 -35.1° 3.8 53.0 -3.6
Prolines* SKGLVLPAVLGITFGAFLIGALLTAALWYIY          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 591, ALA, HA A, 590, ALA, O 3.30Å
B, 594, GLY, HA1 A, 591, ALA, O 2.87Å
B, 595, ILE, HA A, 594, GLY, O 3.02Å
A, 591, ALA, HA B, 590, ALA, O 3.30Å
A, 594, GLY, HA1 B, 591, ALA, O 2.87Å
A, 595, ILE, HA B, 594, GLY, O 3.02Å