HLA class I histocompatibility antigen, alpha chain G

UniProt data

UniProt name: HLAG_HUMAN (P17693)

Gene name: HLA-G; Synonyms=HLA-6.0, HLAG

Organism: Homo sapiens (Human).

Function: Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 309-332, 24 AA, Helical. {ECO:0000255}.

Sequence: 338 AA

10 20 30 40 50 60 MVVMAPRTLF LLLSGALTLT ETWAGSHSMR YFSAAVSRPG RGEPRFIAMG YVDDTQFVRF 70 80 90 100 110 120 DSDSACPRME PRAPWVEQEG PEYWEEETRN TKAHAQTDRM NLQTLRGYYN QSEASSHTLQ 130 140 150 160 170 180 WMIGCDLGSD GRLLRGYEQY AYDGKDYLAL NEDLRSWTAA DTAAQISKRK CEAANVAEQR 190 200 210 220 230 240 RAYLEGTCVE WLHRYLENGK EMLQRADPPK THVTHHPVFD YEATLRCWAL GFYPAEIILT 250 260 270 280 290 300 WQRDGEDQTQ DVELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLMLRWKQ 310 320 330 SSLPTIPIMG IVAGLVVLAA VVTGAAVAAV LWRKKSSD

CATM prediction

The sequence of HLAG_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      310       320       330   
    |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 IAIMGIVAGLVVLAAVVTGAAVAAVLWRKK 6.8 -46.0° 2.7 47.1 -32.0
Model 2 IAIMGIVAGLVVLAAVVTGAAVAAVLWRKK 7.5 -46.0° 2.7 47.0 -5.5
Prolines* IPIMGIVAGLVVLAAVVTGAAVAAVLWRKK          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 321, VAL, HA A, 320, ALA, O 2.86Å
B, 324, GLY, HA1 A, 321, VAL, O 2.79Å
B, 325, ALA, HA A, 324, GLY, O 3.36Å
A, 321, VAL, HA B, 320, ALA, O 2.86Å
A, 324, GLY, HA1 B, 321, VAL, O 2.79Å
A, 325, ALA, HA B, 324, GLY, O 3.36Å