5,6-dihydroxyindole-2-carboxylic acid oxidase

UniProt data

UniProt name: TYRP1_HUMAN (P17643)

Gene name: TYRP1; Synonyms=CAS2, TYRP, TYRRP

Organism: Homo sapiens (Human).

Function: Catalyzes the oxidation of 5,6-dihydroxyindole-2- carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin. {ECO:0000250|UniProtKB:P07147}.

Subcellular location: Melanosome membrane {ECO:0000250|UniProtKB:P07147}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P07147}. Melanosome {ECO:0000250|UniProtKB:P07147}. Note=Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex. Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. {ECO:0000250|UniProtKB:P07147}.

Transmembrane domains:

  1. 478-501, 24 AA, Helical. {ECO:0000255}.

Sequence: 537 AA

10 20 30 40 50 60 MSAPKLLSLG CIFFPLLLFQ QARAQFPRQC ATVEALRSGM CCPDLSPVSG PGTDRCGSSS 70 80 90 100 110 120 GRGRCEAVTA DSRPHSPQYP HDGRDDREVW PLRFFNRTCH CNGNFSGHNC GTCRPGWRGA 130 140 150 160 170 180 ACDQRVLIVR RNLLDLSKEE KNHFVRALDM AKRTTHPLFV IATRRSEEIL GPDGNTPQFE 190 200 210 220 230 240 NISIYNYFVW THYYSVKKTF LGVGQESFGE VDFSHEGPAF LTWHRYHLLR LEKDMQEMLQ 250 260 270 280 290 300 EPSFSLPYWN FATGKNVCDI CTDDLMGSRS NFDSTLISPN SVFSQWRVVC DSLEDYDTLG 310 320 330 340 350 360 TLCNSTEDGP IRRNPAGNVA RPMVQRLPEP QDVAQCLEVG LFDTPPFYSN STNSFRNTVE 370 380 390 400 410 420 GYSDPTGKYD PAVRSLHNLA HLFLNGTGGQ THLSPNDPIF VLLHTFTDAV FDEWLRRYNA 430 440 450 460 470 480 DISTFPLENA PIGHNRQYNM VPFWPPVTNT EMFVTAPDNL GYTYEIQWPS REFSVPEIIA 490 500 510 520 530 IAVVGALLLV ALIFGTASYL IRARRSMDEA NQPLLTDQYQ CYAEEYEKLQ NPNQSVV

CATM prediction

The sequence of TYRP1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       480       490       500  
+    |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 VAEIIAIAVVGALLLVALIFGTASYLIRAR 7.0 -55.1° 2.4 47.6 -13.1
Prolines* VPEIIAIAVVGALLLVALIFGTASYLIRAR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 492, LEU, HA A, 491, ALA, O 3.19Å
B, 495, GLY, HA1 A, 492, LEU, O 2.99Å
A, 492, LEU, HA B, 491, ALA, O 3.19Å
A, 495, GLY, HA1 B, 492, LEU, O 2.99Å