CATM - P17342: Atrial natriuretic peptide receptor 3

UniProt data

Gene name: NPR3; Synonyms=ANPRC, C5orf23, NPRC

Organism: Homo sapiens (Human).

Function: Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

482-504, 23 AA, Helical. {ECO:0000255}.

Sequence: 541 AA

10 20 30 40 50 60 MPSLLVLTFS PCVLLGWALL AGGTGGGGVG GGGGGAGIGG GRQEREALPP QKIEVLVLLP 70 80 90 100 110 120 QDDSYLFSLT RVRPAIEYAL RSVEGNGTGR RLLPPGTRFQ VAYEDSDCGN RALFSLVDRV 130 140 150 160 170 180 AAARGAKPDL ILGPVCEYAA APVARLASHW DLPMLSAGAL AAGFQHKDSE YSHLTRVAPA 190 200 210 220 230 240 YAKMGEMMLA LFRHHHWSRA ALVYSDDKLE RNCYFTLEGV HEVFQEEGLH TSIYSFDETK 250 260 270 280 290 300 DLDLEDIVRN IQASERVVIM CASSDTIRSI MLVAHRHGMT SGDYAFFNIE LFNSSSYGDG 310 320 330 340 350 360 SWKRGDKHDF EAKQAYSSLQ TVTLLRTVKP EFEKFSMEVK SSVEKQGLNM EDYVNMFVEG 370 380 390 400 410 420 FHDAILLYVL ALHEVLRAGY SKKDGGKIIQ QTWNRTFEGI AGQVSIDANG DRYGDFSVIA 430 440 450 460 470 480 MTDVEAGTQE VIGDYFGKEG RFEMRPNVKY PWGPLKLRID ENRIVEHTNS SPCKSSGGLE 490 500 510 520 530 540 ESAVTGIVVG ALLGAGLLMA FYFFRKKYRI TIERRTQQEE SNLGKHRELR EDSIRSHFSV A

CATM prediction

The sequence of ANPRC_HUMAN returned 6 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

#	Sequence and interface	d	θ	Z'	ω'	Score
	480 490 500 \| + \| + \| +	(Å)	(°)	(Å)	(°)
Model 1	LEESAVTGIVVGALLGAGLLMAFYFFRKK	6.4	-34.0°	0.1	57.1	-45.4
Model 2	LEESAVTGIVVGALLGAGLLMAFYFFRKK	6.4	-49.0°	3.9	38.1	-29.5
Model 3	LEESAVTGIVVGALLGAGLLMAFYFFRKK	6.5	-51.0°	4.8	57.2	-27.4
Model 4	LEESAVTGIVVGALLGAGLLMAFYFFRKK	6.9	-54.9°	2.4	48.0	-8.3
Model 5	LEESAVTGIVVGALLGAGLLMAFYFFRKK	7.3	-48.1°	0.8	53.9	-4.8
Model 6	LEESAVTGIVVGALLGAGLLMAFYFFRKK	7.2	-55.0°	0.9	50.2	-3.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:

Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor	Acceptor	Distance
B, 483, ALA, HA	A, 482, SER, O	2.69Å
B, 486, GLY, HA1	A, 483, ALA, O	2.66Å
B, 487, ILE, HA	A, 486, GLY, O	2.45Å
B, 490, GLY, HA1	A, 487, ILE, O	3.42Å
A, 483, ALA, HA	B, 482, SER, O	2.69Å
A, 486, GLY, HA1	B, 483, ALA, O	2.66Å
A, 487, ILE, HA	B, 486, GLY, O	2.45Å
A, 490, GLY, HA1	B, 487, ILE, O	3.42Å

Donor	Acceptor	Distance
B, 490, GLY, HA1	A, 487, ILE, O	3.44Å
B, 491, ALA, HA	A, 490, GLY, O	2.39Å
B, 491, ALA, HA	A, 491, ALA, O	3.45Å
B, 494, GLY, HA1	A, 491, ALA, O	2.53Å
B, 502, TYR, HH	A, 502, TYR, OH	2.16Å
A, 490, GLY, HA1	B, 487, ILE, O	3.44Å
A, 491, ALA, HA	B, 490, GLY, O	2.39Å
A, 491, ALA, HA	B, 491, ALA, O	3.45Å
A, 494, GLY, HA1	B, 491, ALA, O	2.53Å

Donor	Acceptor	Distance
B, 496, GLY, HA1	A, 493, LEU, O	3.44Å
B, 497, LEU, HA	A, 496, GLY, O	3.45Å
A, 496, GLY, HA1	B, 493, LEU, O	3.44Å
A, 497, LEU, HA	B, 496, GLY, O	3.45Å

Donor	Acceptor	Distance
B, 490, GLY, HA1	A, 487, ILE, O	3.27Å
B, 491, ALA, HA	A, 490, GLY, O	3.48Å
B, 502, TYR, HH	A, 502, TYR, OH	2.02Å
A, 490, GLY, HA1	B, 487, ILE, O	3.27Å
A, 491, ALA, HA	B, 490, GLY, O	3.48Å

Donor	Acceptor	Distance
B, 486, GLY, HA1	A, 483, ALA, O	3.37Å
B, 487, ILE, HA	A, 486, GLY, O	2.56Å
B, 490, GLY, HA1	A, 487, ILE, O	3.09Å
A, 482, SER, HG1	B, 482, SER, OG	2.35Å
A, 486, GLY, HA1	B, 483, ALA, O	3.37Å
A, 487, ILE, HA	B, 486, GLY, O	2.56Å
A, 490, GLY, HA1	B, 487, ILE, O	3.09Å

Donor	Acceptor	Distance
B, 483, ALA, HA	A, 482, SER, O	3.16Å
B, 486, GLY, HA1	A, 483, ALA, O	2.84Å
A, 483, ALA, HA	B, 482, SER, O	3.16Å
A, 486, GLY, HA1	B, 483, ALA, O	2.84Å