Integrin alpha-2

UniProt data

UniProt name: ITA2_HUMAN (P17301)

Gene name: ITGA2; Synonyms=CD49B

Organism: Homo sapiens (Human).

Function: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for human rotavirus A (PubMed:12941907). Integrin ITGA2:ITGB1 acts as a receptor for human echoviruses 1 and 8 (PubMed:8411387). {ECO:0000269|PubMed:12941907, ECO:0000269|PubMed:8411387}.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 1133-1154, 22 AA, Helical. {ECO:0000255}.

Sequence: 1181 AA

10 20 30 40 50 60 MGPERTGAAP LPLLLVLALS QGILNCCLAY NVGLPEAKIF SGPSSEQFGY AVQQFINPKG 70 80 90 100 110 120 NWLLVGSPWS GFPENRMGDV YKCPVDLSTA TCEKLNLQTS TSIPNVTEMK TNMSLGLILT 130 140 150 160 170 180 RNMGTGGFLT CGPLWAQQCG NQYYTTGVCS DISPDFQLSA SFSPATQPCP SLIDVVVVCD 190 200 210 220 230 240 ESNSIYPWDA VKNFLEKFVQ GLDIGPTKTQ VGLIQYANNP RVVFNLNTYK TKEEMIVATS 250 260 270 280 290 300 QTSQYGGDLT NTFGAIQYAR KYAYSAASGG RRSATKVMVV VTDGESHDGS MLKAVIDQCN 310 320 330 340 350 360 HDNILRFGIA VLGYLNRNAL DTKNLIKEIK AIASIPTERY FFNVSDEAAL LEKAGTLGEQ 370 380 390 400 410 420 IFSIEGTVQG GDNFQMEMSQ VGFSADYSSQ NDILMLGAVG AFGWSGTIVQ KTSHGHLIFP 430 440 450 460 470 480 KQAFDQILQD RNHSSYLGYS VAAISTGEST HFVAGAPRAN YTGQIVLYSV NENGNITVIQ 490 500 510 520 530 540 AHRGDQIGSY FGSVLCSVDV DKDTITDVLL VGAPMYMSDL KKEEGRVYLF TIKKGILGQH 550 560 570 580 590 600 QFLEGPEGIE NTRFGSAIAA LSDINMDGFN DVIVGSPLEN QNSGAVYIYN GHQGTIRTKY 610 620 630 640 650 660 SQKILGSDGA FRSHLQYFGR SLDGYGDLNG DSITDVSIGA FGQVVQLWSQ SIADVAIEAS 670 680 690 700 710 720 FTPEKITLVN KNAQIILKLC FSAKFRPTKQ NNQVAIVYNI TLDADGFSSR VTSRGLFKEN 730 740 750 760 770 780 NERCLQKNMV VNQAQSCPEH IIYIQEPSDV VNSLDLRVDI SLENPGTSPA LEAYSETAKV 790 800 810 820 830 840 FSIPFHKDCG EDGLCISDLV LDVRQIPAAQ EQPFIVSNQN KRLTFSVTLK NKRESAYNTG 850 860 870 880 890 900 IVVDFSENLF FASFSLPVDG TEVTCQVAAS QKSVACDVGY PALKREQQVT FTINFDFNLQ 910 920 930 940 950 960 NLQNQASLSF QALSESQEEN KADNLVNLKI PLLYDAEIHL TRSTNINFYE ISSDGNVPSI 970 980 990 1000 1010 1020 VHSFEDVGPK FIFSLKVTTG SVPVSMATVI IHIPQYTKEK NPLMYLTGVQ TDKAGDISCN 1030 1040 1050 1060 1070 1080 ADINPLKIGQ TSSSVSFKSE NFRHTKELNC RTASCSNVTC WLKDVHMKGE YFVNVTTRIW 1090 1100 1110 1120 1130 1140 NGTFASSTFQ TVQLTAAAEI NTYNPEIYVI EDNTVTIPLM IMKPDEKAEV PTGVIIGSII 1150 1160 1170 1180 AGILLLLALV AILWKLGFFK RKYEKMTKNP DEIDETTELS S

CATM prediction

The sequence of ITA2_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  1130      1140      1150    
|    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 VATGVIIGSIIAGILLLLALVAILWKLG 6.4 -47.0° 3.3 54.0 -23.7
Model 2 VATGVIIGSIIAGILLLLALVAILWKLG 7.3 -27.0° 6.0 58.0 -15.9
Model 3 VATGVIIGSIIAGILLLLALVAILWKLG 7.1 -55.0° 5.8 47.0 -0.2
Prolines* VPTGVIIGSIIAGILLLLALVAILWKLG          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1134, VAL, HA A, 1133, GLY, O 2.43Å
B, 1137, GLY, HA1 A, 1134, VAL, O 2.58Å
B, 1138, SER, HA A, 1137, GLY, O 3.46Å
A, 1134, VAL, HA B, 1133, GLY, O 2.43Å
A, 1137, GLY, HA1 B, 1134, VAL, O 2.58Å
A, 1138, SER, HA B, 1137, GLY, O 3.46Å