E-selectin

UniProt data

UniProt name: LYAM2_HUMAN (P16581)

Gene name: SELE; Synonyms=ELAM1

Organism: Homo sapiens (Human).

Function: Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis. {ECO:0000269|PubMed:1689848}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:12649084}; Single-pass type I membrane protein.

Transmembrane domains:

  1. 557-578, 22 AA, Helical. {ECO:0000255}.

Sequence: 610 AA

10 20 30 40 50 60 MIASQFLSAL TLVLLIKESG AWSYNTSTEA MTYDEASAYC QQRYTHLVAI QNKEEIEYLN 70 80 90 100 110 120 SILSYSPSYY WIGIRKVNNV WVWVGTQKPL TEEAKNWAPG EPNNRQKDED CVEIYIKREK 130 140 150 160 170 180 DVGMWNDERC SKKKLALCYT AACTNTSCSG HGECVETINN YTCKCDPGFS GLKCEQIVNC 190 200 210 220 230 240 TALESPEHGS LVCSHPLGNF SYNSSCSISC DRGYLPSSME TMQCMSSGEW SAPIPACNVV 250 260 270 280 290 300 ECDAVTNPAN GFVECFQNPG SFPWNTTCTF DCEEGFELMG AQSLQCTSSG NWDNEKPTCK 310 320 330 340 350 360 AVTCRAVRQP QNGSVRCSHS PAGEFTFKSS CNFTCEEGFM LQGPAQVECT TQGQWTQQIP 370 380 390 400 410 420 VCEAFQCTAL SNPERGYMNC LPSASGSFRY GSSCEFSCEQ GFVLKGSKRL QCGPTGEWDN 430 440 450 460 470 480 EKPTCEAVRC DAVHQPPKGL VRCAHSPIGE FTYKSSCAFS CEEGFELHGS TQLECTSQGQ 490 500 510 520 530 540 WTEEVPSCQV VKCSSLAVPG KINMSCSGEP VFGTVCKFAC PEGWTLNGSA ARTCGATGHW 550 560 570 580 590 600 SGLLPTCEAP TESNIPLVAG LSAAGLSLLT LAPFLLWLRK CLRKAKKFVP ASSCQSLESD GSYQKPSYIL

CATM prediction

The sequence of LYAM2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        560       570       58
 +    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 NIALVAGLSAAGLSLLTLAAFLLWLRKC 7.1 -40.0° 4.5 44.0 -20.5
Prolines* NIPLVAGLSAAGLSLLTLAPFLLWLRKC          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 560, GLY, HA1 A, 557, LEU, O 3.29Å
A, 560, GLY, HA1 B, 557, LEU, O 3.29Å