Epithelial cell adhesion molecule

UniProt data

UniProt name: EPCAM_HUMAN (P16422)

Gene name: EPCAM; Synonyms=GA733-2, M1S2, M4S1, MIC18, TACSTD1, TROP1

Organism: Homo sapiens (Human).

Function: May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E. {ECO:0000269|PubMed:15195135, ECO:0000269|PubMed:15922867, ECO:0000269|PubMed:19785009, ECO:0000269|PubMed:20064925}.

Subcellular location: Lateral cell membrane {ECO:0000269|PubMed:15195135, ECO:0000269|PubMed:16054130, ECO:0000269|PubMed:19785009}; Single-pass type I membrane protein {ECO:0000269|PubMed:16054130}. Cell junction, tight junction {ECO:0000269|PubMed:16054130}. Note=Colocalizes with CLDN7 at the lateral cell membrane and tight junction. {ECO:0000269|PubMed:16054130}.

Transmembrane domains:

  1. 266-288, 23 AA, Helical. {ECO:0000255}.

Sequence: 314 AA

10 20 30 40 50 60 MAPPQVLAFG LLLAAATATF AAAQEECVCE NYKLAVNCFV NNNRQCQCTS VGAQNTVICS 70 80 90 100 110 120 KLAAKCLVMK AEMNGSKLGR RAKPEGALQN NDGLYDPDCD ESGLFKAKQC NGTSMCWCVN 130 140 150 160 170 180 TAGVRRTDKD TEITCSERVR TYWIIIELKH KAREKPYDSK SLRTALQKEI TTRYQLDPKF 190 200 210 220 230 240 ITSILYENNV ITIDLVQNSS QKTQNDVDIA DVAYYFEKDV KGESLFHSKK MDLTVNGEQL 250 260 270 280 290 300 DLDPGQTLIY YVDEKAPEFS MQGLKAGVIA VIVVVVIAVV AGIVVLVISR KKRMAKYEKA 310 EIKEMGEMHR ELNA

CATM prediction

The sequence of EPCAM_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         270       280       29
  +    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 GLKAGVIAVIVVVVIAVVAGIVVLVISRK 6.7 -53.0° 5.2 58.0 -2.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session