Cytotoxic T-lymphocyte protein 4

UniProt data

UniProt name: CTLA4_HUMAN (P16410)

Gene name: CTLA4; Synonyms=CD152

Organism: Homo sapiens (Human).

Function: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. {ECO:0000269|PubMed:16551244, ECO:0000269|PubMed:1714933}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:18468488}; Single-pass type I membrane protein {ECO:0000269|PubMed:18468488}. Note=Exists primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid internalisation;.

Transmembrane domains:

  1. 162-182, 21 AA, Helical. {ECO:0000255}.

Sequence: 223 AA

10 20 30 40 50 60 MACLGFQRHK AQLNLATRTW PCTLLFFLLF IPVFCKAMHV AQPAVVLASS RGIASFVCEY 70 80 90 100 110 120 ASPGKATEVR VTVLRQADSQ VTEVCAATYM MGNELTFLDD SICTGTSSGN QVNLTIQGLR 130 140 150 160 170 180 AMDTGLYICK VELMYPPPYY LGIGNGTQIY VIDPEPCPDS DFLLWILAAV SSGLFFYSFL 190 200 210 220 LTAVSLSKML KKRSPLTTGV YVKMPPTEPE CEKQFQPYFI PIN

CATM prediction

The sequence of CTLA4_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   160       170       180   
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 DSDFLLWILAAVSSGLFFYSFLLTAVS 7.2 -50.7° 3.3 47.9 -17.7

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 170, VAL, HA A, 169, ALA, O 3.16Å
B, 173, GLY, HA1 A, 170, VAL, O 3.23Å
B, 178, SER, HG1 A, 177, TYR, OH 2.14Å
A, 170, VAL, HA B, 169, ALA, O 3.16Å
A, 173, GLY, HA1 B, 170, VAL, O 3.23Å
A, 178, SER, HG1 B, 177, TYR, OH 2.14Å