UniProt data
UniProt name: LYAM3_HUMAN (P16109)
SELP; Synonyms=GMRP, GRMP
Homo sapiens (Human).
Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. {ECO:0000269|PubMed:7585950}.
Membrane; Single-pass type I membrane protein.
- 772-795, 24 AA, Helical. {ECO:0000255}.
830 AA
10 20 30 40 50 60
MANCQIAILY QRFQRVVFGI SQLLCFSALI SELTNQKEVA AWTYHYSTKA YSWNISRKYC
70 80 90 100 110 120
QNRYTDLVAI QNKNEIDYLN KVLPYYSSYY WIGIRKNNKT WTWVGTKKAL TNEAENWADN
130 140 150 160 170 180
EPNNKRNNED CVEIYIKSPS APGKWNDEHC LKKKHALCYT ASCQDMSCSK QGECLETIGN
190 200 210 220 230 240
YTCSCYPGFY GPECEYVREC GELELPQHVL MNCSHPLGNF SFNSQCSFHC TDGYQVNGPS
250 260 270 280 290 300
KLECLASGIW TNKPPQCLAA QCPPLKIPER GNMTCLHSAK AFQHQSSCSF SCEEGFALVG
310 320 330 340 350 360
PEVVQCTASG VWTAPAPVCK AVQCQHLEAP SEGTMDCVHP LTAFAYGSSC KFECQPGYRV
370 380 390 400 410 420
RGLDMLRCID SGHWSAPLPT CEAISCEPLE SPVHGSMDCS PSLRAFQYDT NCSFRCAEGF
430 440 450 460 470 480
MLRGADIVRC DNLGQWTAPA PVCQALQCQD LPVPNEARVN CSHPFGAFRY QSVCSFTCNE
490 500 510 520 530 540
GLLLVGASVL QCLATGNWNS VPPECQAIPC TPLLSPQNGT MTCVQPLGSS SYKSTCQFIC
550 560 570 580 590 600
DEGYSLSGPE RLDCTRSGRW TDSPPMCEAI KCPELFAPEQ GSLDCSDTRG EFNVGSTCHF
610 620 630 640 650 660
SCDNGFKLEG PNNVECTTSG RWSATPPTCK GIASLPTPGL QCPALTTPGQ GTMYCRHHPG
670 680 690 700 710 720
TFGFNTTCYF GCNAGFTLIG DSTLSCRPSG QWTAVTPACR AVKCSELHVN KPIAMNCSNL
730 740 750 760 770 780
WGNFSYGSIC SFHCLEGQLL NGSAQTACQE NGHWSTTVPT CQAGPLTIQE ALTYFGGAVA
790 800 810 820
STIGLIMGGT LLALLRKRFR QKDDGKCPLN PHSHLGTYGV FTNAAFDPSP
CATM prediction
The sequence of LYAM3_HUMAN returned 7 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # |
Sequence and interface |
d |
θ |
Z' |
ω' |
Score |
| |
770 780 790
| + | + | + |
(Å) |
(°) |
(Å) |
(°) |
|
| Model 1 |
QEALTYFGGAVASTIGLIMGGTLLALLRKR |
7.1 |
-31.2° |
4.0 |
51.1 |
-33.3 |
| Model 2 |
QEALTYFGGAVASTIGLIMGGTLLALLRKR |
6.6 |
-50.9° |
2.4 |
44.9 |
-20.7 |
| Model 3 |
QEALTYFGGAVASTIGLIMGGTLLALLRKR |
7.2 |
-52.7° |
2.0 |
44.8 |
-20.2 |
| Model 4 |
QEALTYFGGAVASTIGLIMGGTLLALLRKR |
7.3 |
-53.1° |
3.1 |
34.4 |
-18.2 |
| Model 5 |
QEALTYFGGAVASTIGLIMGGTLLALLRKR |
6.8 |
-55.1° |
1.5 |
45.2 |
-14.0 |
| Model 6 |
QEALTYFGGAVASTIGLIMGGTLLALLRKR |
7.0 |
-38.1° |
5.7 |
34.1 |
-13.9 |
| Model 7 |
QEALTYFGGAVASTIGLIMGGTLLALLRKR |
6.6 |
-51.0° |
1.2 |
44.9 |
-8.2 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Click on the image to enlarge
PDB, PyMOL session
| Donor |
Acceptor |
Distance |
| B, 781, SER, HA |
A, 780, ALA, O |
2.89Å |
| B, 784, GLY, HA1 |
A, 781, SER, O |
3.36Å |
| A, 773, THR, HG1 |
B, 773, THR, OG1 |
2.26Å |
| A, 781, SER, HA |
B, 780, ALA, O |
2.89Å |
| A, 784, GLY, HA1 |
B, 781, SER, O |
3.36Å |
MODEL 2 DETAILS
Click on the image to enlarge
PDB, PyMOL session
| Donor |
Acceptor |
Distance |
| B, 781, SER, HA |
A, 780, ALA, O |
2.80Å |
| B, 784, GLY, HA1 |
A, 781, SER, O |
2.58Å |
| B, 785, LEU, HA |
A, 784, GLY, O |
3.45Å |
| A, 781, SER, HA |
B, 780, ALA, O |
2.80Å |
| A, 784, GLY, HA1 |
B, 781, SER, O |
2.58Å |
| A, 785, LEU, HA |
B, 784, GLY, O |
3.45Å |
MODEL 3 DETAILS
Click on the image to enlarge
PDB, PyMOL session
| Donor |
Acceptor |
Distance |
| B, 786, ILE, HA |
A, 785, LEU, O |
3.50Å |
| B, 789, GLY, HA1 |
A, 786, ILE, O |
3.10Å |
| A, 786, ILE, HA |
B, 785, LEU, O |
3.50Å |
| A, 789, GLY, HA1 |
B, 786, ILE, O |
3.10Å |
MODEL 4 DETAILS
Click on the image to enlarge
PDB, PyMOL session
| Donor |
Acceptor |
Distance |
| B, 785, LEU, HA |
A, 784, GLY, O |
3.42Å |
| B, 788, GLY, HA1 |
A, 785, LEU, O |
3.16Å |
| A, 785, LEU, HA |
B, 784, GLY, O |
3.42Å |
| A, 788, GLY, HA1 |
B, 785, LEU, O |
3.16Å |
MODEL 5 DETAILS
Click on the image to enlarge
PDB, PyMOL session
| Donor |
Acceptor |
Distance |
| B, 774, TYR, HA |
A, 773, THR, O |
3.35Å |
| B, 777, GLY, HA1 |
A, 774, TYR, O |
2.76Å |
| B, 778, ALA, HA |
A, 777, GLY, O |
3.26Å |
| B, 781, SER, HG1 |
A, 778, ALA, O |
2.72Å |
| B, 778, ALA, HA |
A, 781, SER, OG |
2.90Å |
| A, 774, TYR, HA |
B, 773, THR, O |
3.35Å |
| A, 777, GLY, HA1 |
B, 774, TYR, O |
2.76Å |
| A, 778, ALA, HA |
B, 777, GLY, O |
3.26Å |
MODEL 6 DETAILS
Click on the image to enlarge
PDB, PyMOL session
| Donor |
Acceptor |
Distance |
| B, 773, THR, HA |
A, 773, THR, OG1 |
3.25Å |
| B, 776, GLY, HA1 |
A, 773, THR, O |
3.43Å |
| B, 777, GLY, HA2 |
A, 776, GLY, O |
3.03Å |
| A, 773, THR, HA |
B, 773, THR, OG1 |
3.25Å |
| A, 776, GLY, HA1 |
B, 773, THR, O |
3.43Å |
| A, 777, GLY, HA2 |
B, 776, GLY, O |
3.03Å |
MODEL 7 DETAILS
Click on the image to enlarge
PDB, PyMOL session
| Donor |
Acceptor |
Distance |
| B, 773, THR, HA |
A, 772, LEU, O |
3.13Å |
| B, 776, GLY, HA1 |
A, 773, THR, O |
2.59Å |
| B, 777, GLY, HA2 |
A, 776, GLY, O |
2.91Å |
| A, 773, THR, HA |
B, 772, LEU, O |
3.13Å |
| A, 776, GLY, HA1 |
B, 773, THR, O |
2.59Å |
| A, 777, GLY, HA2 |
B, 776, GLY, O |
2.91Å |
