Amphiregulin {ECO:0000303|PubMed:2325643}

UniProt data

UniProt name: AREG_HUMAN (P15514)

Gene name: AREG {ECO:0000312|HGNC:HGNC:651}

Organism: Homo sapiens (Human).

Function: Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.

Subcellular location: Membrane; Single-pass membrane protein.

Transmembrane domains:

  1. 199-221, 23 AA, Helical. {ECO:0000255}.

Sequence: 252 AA

10 20 30 40 50 60 MRAPLLPPAP VVLSLLILGS GHYAAGLDLN DTYSGKREPF SGDHSADGFE VTSRSEMSSG 70 80 90 100 110 120 SEISPVSEMP SSSEPSSGAD YDYSEEYDNE PQIPGYIVDD SVRVEQVVKP PQNKTESENT 130 140 150 160 170 180 SDKPKRKKKG GKNGKNRRNR KKKNPCNAEF QNFCIHGECK YIEHLEAVTC KCQQEYFGER 190 200 210 220 230 240 CGEKSMKTHS MIDSSLSKIA LAAIAAFMSA VILTAVAVIT VQLRRQYVRK YEGEAEERKK 250 LRQENGNVHA IA

CATM prediction

The sequence of AREG_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      200       210       220  
    |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 LSKIALAAIAAFMSAVILTAVAVITVQLR 7.2 -37.0° 2.3 36.2 -4.0

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 203, ALA, HA A, 202, ALA, O 3.46Å
B, 207, PHE, HA A, 206, ALA, O 3.39Å
A, 203, ALA, HA B, 202, ALA, O 3.46Å
A, 207, PHE, HA B, 206, ALA, O 3.39Å