Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

UniProt data

UniProt name: CSF2R_HUMAN (P15509)

Gene name: CSF2RA; Synonyms=CSF2R, CSF2RY

Organism: Homo sapiens (Human).

Function: Low affinity receptor for granulocyte-macrophage colony- stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.

Subcellular location: Isoform 6: Secreted {ECO:0000305}.

Transmembrane domains:

  1. 321-346, 26 AA, Helical. {ECO:0000255}.

Sequence: 400 AA

10 20 30 40 50 60 MLLLVTSLLL CELPHPAFLL IPEKSDLRTV APASSLNVRF DSRTMNLSWD CQENTTFSKC 70 80 90 100 110 120 FLTDKKNRVV EPRLSNNECS CTFREICLHE GVTFEVHVNT SQRGFQQKLL YPNSGREGTA 130 140 150 160 170 180 AQNFSCFIYN ADLMNCTWAR GPTAPRDVQY FLYIRNSKRR REIRCPYYIQ DSGTHVGCHL 190 200 210 220 230 240 DNLSGLTSRN YFLVNGTSRE IGIQFFDSLL DTKKIERFNP PSNVTVRCNT THCLVRWKQP 250 260 270 280 290 300 RTYQKLSYLD FQYQLDVHRK NTQPGTENLL INVSGDLENR YNFPSSEPRA KHSVKIRAAD 310 320 330 340 350 360 VRILNWSSWS EAIEFGSDDG NLGSVYIYVL LIVGTLVCGI VLGFLFKRFL RIQRLFPPVP 370 380 390 QIKDKLNDNH EVEDEIIWEE FTPEEGKGYR EEVLTVKEIT

CATM prediction

The sequence of CSF2R_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    320       330       340       
  |    +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 DDGNLGSVYIYVLLIVGTLVCGIVLGFLFKRF 6.6 -51.7° 4.8 57.1 -41.2
Model 2 DDGNLGSVYIYVLLIVGTLVCGIVLGFLFKRF 7.3 -36.0° 0.9 56.2 -25.3
Model 3 DDGNLGSVYIYVLLIVGTLVCGIVLGFLFKRF 7.2 -54.9° 0.9 50.0 -4.7

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 339, GLY, HA1 A, 336, LEU, O 3.23Å
B, 340, ILE, HA A, 339, GLY, O 2.64Å
B, 343, GLY, HA1 A, 340, ILE, O 3.31Å
A, 339, GLY, HA1 B, 336, LEU, O 3.23Å
A, 340, ILE, HA B, 339, GLY, O 2.64Å
A, 343, GLY, HA1 B, 340, ILE, O 3.31Å