Potassium voltage-gated channel subfamily E member 1

UniProt data

UniProt name: KCNE1_HUMAN (P15382)

Gene name: KCNE1

Organism: Homo sapiens (Human).

Function: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:19219384). Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr). {ECO:0000269|PubMed:19219384}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:19219384}; Single-pass type I membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000250|UniProtKB:P15383}. Membrane raft {ECO:0000269|PubMed:20533308}. Note=Colocalizes with KCNB1 at the plasma membrane (By similarity). Targets to the membrane raft when associated with KNCQ1 (PubMed:20533308). {ECO:0000250|UniProtKB:P15383, ECO:0000269|PubMed:20533308}.

Transmembrane domains:

  1. 44-66, 23 AA, Helical. {ECO:0000255}.

Sequence: 129 AA

10 20 30 40 50 60 MILSNTTAVT PFLTKLWQET VQQGGNMSGL ARRSPRSSDG KLEALYVLMV LGFFGFFTLG 70 80 90 100 110 120 IMLSYIRSKK LEHSNDPFNV YIESDAWQEK DKAYVQARVL ESYRSCYVVE NHLAIEQPNT HLPETKPSP

CATM prediction

The sequence of KCNE1_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           50        60        
    +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 KLEALYVLMVLGFFGFFTLGIMLSYIRSK 7.0 -55.0° 0.9 50.3 -20.7
Model 2 KLEALYVLMVLGFFGFFTLGIMLSYIRSK 7.3 -40.0° 1.9 44.1 -2.8

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 60, GLY, HA1 A, 57, PHE, O 3.09Å
B, 61, ILE, HA A, 60, GLY, O 3.12Å
B, 64, SER, HG1 A, 61, ILE, O 2.42Å
A, 60, GLY, HA1 B, 57, PHE, O 3.09Å
A, 61, ILE, HA B, 60, GLY, O 3.12Å
A, 64, SER, HG1 B, 61, ILE, O 2.42Å