Poliovirus receptor

UniProt data

UniProt name: PVR_HUMAN (P15151)

Gene name: PVR; Synonyms=PVS

Organism: Homo sapiens (Human).

Function: (Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport (PubMed:2538245). Acts as a receptor for pseudorabies virus (PubMed:9616127). Is prevented to reach cell surface upon infection by human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells (PubMed:15640804). {ECO:0000269|PubMed:15640804, ECO:0000269|PubMed:2538245, ECO:0000269|PubMed:9616127}.

Subcellular location: Isoform Gamma: Secreted.

Transmembrane domains:

  1. 344-367, 24 AA, Helical. {ECO:0000255}.

Sequence: 417 AA

10 20 30 40 50 60 MARAMAAAWP LLLVALLVLS WPPPGTGDVV VQAPTQVPGF LGDSVTLPCY LQVPNMEVTH 70 80 90 100 110 120 VSQLTWARHG ESGSMAVFHQ TQGPSYSESK RLEFVAARLG AELRNASLRM FGLRVEDEGN 130 140 150 160 170 180 YTCLFVTFPQ GSRSVDIWLR VLAKPQNTAE VQKVQLTGEP VPMARCVSTG GRPPAQITWH 190 200 210 220 230 240 SDLGGMPNTS QVPGFLSGTV TVTSLWILVP SSQVDGKNVT CKVEHESFEK PQLLTVNLTV 250 260 270 280 290 300 YYPPEVSISG YDNNWYLGQN EATLTCDARS NPEPTGYNWS TTMGPLPPFA VAQGAQLLIR 310 320 330 340 350 360 PVDKPINTTL ICNVTNALGA RQAELTVQVK EGPPSEHSGI SRNAIIFLVL GILVFLILLG 370 380 390 400 410 IGIYFYWSKC SREVLWHCHL CPSSTEHASA SANGHVSYSA VSRENSSSQD PQTEGTR

CATM prediction

The sequence of PVR_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           350       360       3
    +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 SRNAIIFLVLGILVFLILLGIGIYFYWSKC 7.3 -54.0° 2.8 50.9 -7.2

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 348, LEU, HA A, 347, PHE, O 3.49Å
B, 351, GLY, HA1 A, 348, LEU, O 3.47Å
A, 348, LEU, HA B, 347, PHE, O 3.49Å
A, 351, GLY, HA1 B, 348, LEU, O 3.47Å