Aminopeptidase N

UniProt data

UniProt name: AMPN_HUMAN (P15144)

Gene name: ANPEP; Synonyms=APN, CD13, PEPN

Organism: Homo sapiens (Human).

Function: (Microbial infection) Acts as a receptor for human coronavirus 229E/HCoV-229E. {ECO:0000269|PubMed:12551991, ECO:0000269|PubMed:1350662}.

Subcellular location: Cell membrane; Single-pass type II membrane protein. Cytoplasm, cytosol {ECO:0000305}. Note=A soluble form has also been detected.

Transmembrane domains:

  1. 9-32, 24 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 967 AA

10 20 30 40 50 60 MAKGFYISKS LGILGILLGV AAVCTIIALS VVYSQEKNKN ANSSPVASTT PSASATTNPA 70 80 90 100 110 120 SATTLDQSKA WNRYRLPNTL KPDSYRVTLR PYLTPNDRGL YVFKGSSTVR FTCKEATDVI 130 140 150 160 170 180 IIHSKKLNYT LSQGHRVVLR GVGGSQPPDI DKTELVEPTE YLVVHLKGSL VKDSQYEMDS 190 200 210 220 230 240 EFEGELADDL AGFYRSEYME GNVRKVVATT QMQAADARKS FPCFDEPAMK AEFNITLIHP 250 260 270 280 290 300 KDLTALSNML PKGPSTPLPE DPNWNVTEFH TTPKMSTYLL AFIVSEFDYV EKQASNGVLI 310 320 330 340 350 360 RIWARPSAIA AGHGDYALNV TGPILNFFAG HYDTPYPLPK SDQIGLPDFN AGAMENWGLV 370 380 390 400 410 420 TYRENSLLFD PLSSSSSNKE RVVTVIAHEL AHQWFGNLVT IEWWNDLWLN EGFASYVEYL 430 440 450 460 470 480 GADYAEPTWN LKDLMVLNDV YRVMAVDALA SSHPLSTPAS EINTPAQISE LFDAISYSKG 490 500 510 520 530 540 ASVLRMLSSF LSEDVFKQGL ASYLHTFAYQ NTIYLNLWDH LQEAVNNRSI QLPTTVRDIM 550 560 570 580 590 600 NRWTLQMGFP VITVDTSTGT LSQEHFLLDP DSNVTRPSEF NYVWIVPITS IRDGRQQQDY 610 620 630 640 650 660 WLIDVRAQND LFSTSGNEWV LLNLNVTGYY RVNYDEENWR KIQTQLQRDH SAIPVINRAQ 670 680 690 700 710 720 IINDAFNLAS AHKVPVTLAL NNTLFLIEER QYMPWEAALS SLSYFKLMFD RSEVYGPMKN 730 740 750 760 770 780 YLKKQVTPLF IHFRNNTNNW REIPENLMDQ YSEVNAISTA CSNGVPECEE MVSGLFKQWM 790 800 810 820 830 840 ENPNNNPIHP NLRSTVYCNA IAQGGEEEWD FAWEQFRNAT LVNEADKLRA ALACSKELWI 850 860 870 880 890 900 LNRYLSYTLN PDLIRKQDAT STIISITNNV IGQGLVWDFV QSNWKKLFND YGGGSFSFSN 910 920 930 940 950 960 LIQAVTRRFS TEYELQQLEQ FKKDNEETGF GSGTRALEQA LEKTKANIKW VKENKEVVLQ WFTENSK

CATM prediction

The sequence of AMPN_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      10        20        30    
    |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 YISKSLGILGILLGVAAVCTIIALSVVYSQ 6.8 -47.8° 0.8 53.9 -19.8
Model 2 YISKSLGILGILLGVAAVCTIIALSVVYSQ 7.0 +51.4° 3.9 72.2 -2.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 12, GLY, HA2 A, 11, LEU, O 3.34Å
B, 15, GLY, HA1 A, 12, GLY, O 2.92Å
B, 16, ILE, HA A, 15, GLY, O 2.93Å
A, 12, GLY, HA2 B, 11, LEU, O 3.34Å
A, 15, GLY, HA1 B, 12, GLY, O 2.92Å
A, 16, ILE, HA B, 15, GLY, O 2.93Å