Interleukin-2 receptor subunit beta

UniProt data

UniProt name: IL2RB_HUMAN (P14784)

Gene name: IL2RB

Organism: Homo sapiens (Human).

Function: Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 241-265, 25 AA, Helical. {ECO:0000255}.

Sequence: 551 AA

10 20 30 40 50 60 MAAPALSWRL PLLILLLPLA TSWASAAVNG TSQFTCFYNS RANISCVWSQ DGALQDTSCQ 70 80 90 100 110 120 VHAWPDRRRW NQTCELLPVS QASWACNLIL GAPDSQKLTT VDIVTLRVLC REGVRWRVMA 130 140 150 160 170 180 IQDFKPFENL RLMAPISLQV VHVETHRCNI SWEISQASHY FERHLEFEAR TLSPGHTWEE 190 200 210 220 230 240 APLLTLKQKQ EWICLETLTP DTQYEFQVRV KPLQGEFTTW SPWSQPLAFR TKPAALGKDT 250 260 270 280 290 300 IPWLGHLLVG LSGAFGFIIL VYLLINCRNT GPWLKKVLKC NTPDPSKFFS QLSSEHGGDV 310 320 330 340 350 360 QKWLSSPFPS SSFSPGGLAP EISPLEVLER DKVTQLLLQQ DKVPEPASLS SNHSLTSCFT 370 380 390 400 410 420 NQGYFFFHLP DALEIEACQV YFTYDPYSEE DPDEGVAGAP TGSSPQPLQP LSGEDDAYCT 430 440 450 460 470 480 FPSRDDLLLF SPSLLGGPSP PSTAPGGSGA GEERMPPSLQ ERVPRDWDPQ PLGPPTPGVP 490 500 510 520 530 540 DLVDFQPPPE LVLREAGEEV PDAGPREGVS FPWSRPPGQG EFRALNARLP LNTDAYLSLQ 550 ELQGQDPTHL V

CATM prediction

The sequence of IL2RB_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    240       250       260      
  |    +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 KDTIAWLGHLLVGLSGAFGFIILVYLLINCR 6.9 -52.1° 1.4 56.9 -28.2
Model 2 KDTIAWLGHLLVGLSGAFGFIILVYLLINCR 7.3 -53.7° 3.6 34.7 -15.1
Model 3 KDTIAWLGHLLVGLSGAFGFIILVYLLINCR 7.1 +52.0° 1.8 0.6 -4.9
Prolines* KDTIPWLGHLLVGLSGAFGFIILVYLLINCR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 247, LEU, HA A, 246, HSE, O 3.47Å
B, 250, GLY, HA1 A, 247, LEU, O 3.07Å
B, 251, LEU, HA A, 250, GLY, O 3.35Å
A, 247, LEU, HA B, 246, HSE, O 3.47Å
A, 250, GLY, HA1 B, 247, LEU, O 3.07Å
A, 251, LEU, HA B, 250, GLY, O 3.35Å
A, 262, TYR, HH B, 262, TYR, OH 2.28Å