Interleukin-1 receptor type 1

UniProt data

UniProt name: IL1R1_HUMAN (P14778)

Gene name: IL1R1; Synonyms=IL1R, IL1RA, IL1RT1

Organism: Homo sapiens (Human).

Function: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. {ECO:0000269|PubMed:10671496}.

Subcellular location: Membrane {ECO:0000269|PubMed:8142597}; Single-pass type I membrane protein {ECO:0000269|PubMed:8142597}. Cell membrane {ECO:0000305|PubMed:8142597}. Secreted {ECO:0000269|PubMed:8142597}.

Transmembrane domains:

  1. 337-356, 20 AA, Helical. {ECO:0000255}.

Sequence: 569 AA

10 20 30 40 50 60 MKVLLRLICF IALLISSLEA DKCKEREEKI ILVSSANEID VRPCPLNPNE HKGTITWYKD 70 80 90 100 110 120 DSKTPVSTEQ ASRIHQHKEK LWFVPAKVED SGHYYCVVRN SSYCLRIKIS AKFVENEPNL 130 140 150 160 170 180 CYNAQAIFKQ KLPVAGDGGL VCPYMEFFKN ENNELPKLQW YKDCKPLLLD NIHFSGVKDR 190 200 210 220 230 240 LIVMNVAEKH RGNYTCHASY TYLGKQYPIT RVIEFITLEE NKPTRPVIVS PANETMEVDL 250 260 270 280 290 300 GSQIQLICNV TGQLSDIAYW KWNGSVIDED DPVLGEDYYS VENPANKRRS TLITVLNISE 310 320 330 340 350 360 IESRFYKHPF TCFAKNTHGI DAAYIQLIYP VTNFQKHMIG ICVTLTVIIV CSVFIYKIFK 370 380 390 400 410 420 IDIVLWYRDS CYDFLPIKAS DGKTYDAYIL YPKTVGEGST SDCDIFVFKV LPEVLEKQCG 430 440 450 460 470 480 YKLFIYGRDD YVGEDIVEVI NENVKKSRRL IIILVRETSG FSWLGGSSEE QIAMYNALVQ 490 500 510 520 530 540 DGIKVVLLEL EKIQDYEKMP ESIKFIKQKH GAIRWSGDFT QGPQSAKTRF WKNVRYHMPV 550 560 QRRSPSSKHQ LLSPATKEKL QREAHVPLG

CATM prediction

The sequence of IL1R1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        340       350       
 +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 FQKHMIGICVTLTVIIVCSVFIYKIF 7.1 -45.7° 2.7 47.1 -17.7

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 340, GLY, HA1 A, 337, HSE, O 3.10Å
B, 341, ILE, HA A, 344, THR, OG1 2.40Å
A, 340, GLY, HA1 B, 337, HSE, O 3.10Å
A, 341, ILE, HA B, 344, THR, OG1 2.40Å