CD99 antigen

UniProt data

UniProt name: CD99_HUMAN (P14209)

Gene name: CD99; Synonyms=MIC2, MIC2X, MIC2Y

Organism: Homo sapiens (Human).

Function: Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity). {ECO:0000250}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 123-147, 25 AA, Helical. {ECO:0000255}.

Sequence: 185 AA

10 20 30 40 50 60 MARGAALALL LFGLLGVLVA APDGGFDLSD ALPDNENKKP TAIPKKPSAG DDFDLGDAVV 70 80 90 100 110 120 DGENDDPRPP NPPKPMPNPN PNHPSSSGSF SDADLADGVS GGEGKGGSDG GGSHRKEGEE 130 140 150 160 170 180 ADAPGVIPGI VGAVVVAVAG AISSFIAYQK KKLCFKENAE QGEVDMESHR NANAEPAVQR TLLEK

CATM prediction

The sequence of CD99_HUMAN returned 10 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  120       130       140       1
|    +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 EADAAGVIAGIVGAVVVAVAGAISSFIAYQK 6.4 -46.7° 3.3 54.1 -27.6
Model 2 EADAAGVIAGIVGAVVVAVAGAISSFIAYQK 7.4 -20.0° 2.1 45.0 -22.0
Model 3 EADAAGVIAGIVGAVVVAVAGAISSFIAYQK 6.7 -32.0° 2.2 53.0 -20.4
Model 4 EADAAGVIAGIVGAVVVAVAGAISSFIAYQK 7.0 -52.9° 3.1 33.9 -20.0
Model 5 EADAAGVIAGIVGAVVVAVAGAISSFIAYQK 7.0 -42.8° 4.5 35.3 -19.3
Model 6 EADAAGVIAGIVGAVVVAVAGAISSFIAYQK 7.4 -41.0° 3.5 37.6 -18.3
Model 7 EADAAGVIAGIVGAVVVAVAGAISSFIAYQK 7.2 -50.9° 1.2 45.2 -13.5
Model 8 EADAAGVIAGIVGAVVVAVAGAISSFIAYQK 6.7 +48.0° 1.9 0.1 -8.9
Model 9 EADAAGVIAGIVGAVVVAVAGAISSFIAYQK 7.1 -46.0° 2.7 47.0 -8.4
Model 10 EADAAGVIAGIVGAVVVAVAGAISSFIAYQK 7.3 -43.2° 6.0 43.9 -6.2
Prolines* EADAPGVIPGIVGAVVVAVAGAISSFIAYQK          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 126, VAL, HA A, 125, GLY, O 2.41Å
B, 129, GLY, HA1 A, 126, VAL, O 2.57Å
B, 130, ILE, HA A, 129, GLY, O 3.44Å
A, 126, VAL, HA B, 125, GLY, O 2.41Å
A, 129, GLY, HA1 B, 126, VAL, O 2.57Å
A, 130, ILE, HA B, 129, GLY, O 3.44Å