HLA class II histocompatibility antigen, DO beta chain

UniProt data

UniProt name: DOB_HUMAN (P13765)

Gene name: HLA-DOB

Organism: Homo sapiens (Human).

Function: Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.

Subcellular location: Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.

Transmembrane domains:

  1. 225-245, 21 AA, Helical. {ECO:0000255}.

Sequence: 273 AA

10 20 30 40 50 60 MGSGWVPWVV ALLVNLTRLD SSMTQGTDSP EDFVIQAKAD CYFTNGTEKV QFVVRFIFNL 70 80 90 100 110 120 EEYVRFDSDV GMFVALTKLG QPDAEQWNSR LDLLERSRQA VDGVCRHNYR LGAPFTVGRK 130 140 150 160 170 180 VQPEVTVYPE RTPLLHQHNL LHCSVTGFYP GDIKIKWFLN GQEERAGVMS TGPIRNGDWT 190 200 210 220 230 240 FQTVVMLEMT PELGHVYTCL VDHSSLLSPV SVEWRAQSEY SWRKMLSGIA AFLLGLIFLL 250 260 270 VGIVIQLRAQ KGYVRTQMSG NEVSRAVLLP QSC

CATM prediction

The sequence of DOB_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          230       240      
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 WRKMLSGIAAFLLGLIFLLVGIVIQLR 7.0 -43.1° 5.5 33.9 -26.3
Model 2 WRKMLSGIAAFLLGLIFLLVGIVIQLR 7.1 -55.0° 2.4 47.9 -25.8
Model 3 WRKMLSGIAAFLLGLIFLLVGIVIQLR 7.2 -51.0° 4.3 40.0 -23.3
Model 4 WRKMLSGIAAFLLGLIFLLVGIVIQLR 7.0 -36.1° 1.5 36.4 -1.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 239, LEU, HA A, 238, PHE, O 3.10Å
B, 242, GLY, HA1 A, 239, LEU, O 3.41Å
A, 239, LEU, HA B, 238, PHE, O 3.10Å
A, 242, GLY, HA1 B, 239, LEU, O 3.41Å