UniProt data
UniProt name: HLAE_HUMAN (P13747)
Gene name: HLA-E; Synonyms=HLA-6.2, HLAE
Organism: Homo sapiens (Human).
Function: Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules.
Subcellular location: Membrane; Single-pass type I membrane protein.
Transmembrane domains:
- 306-329, 24 AA, Helical. {ECO:0000255}.
Sequence: 358 AA
CATM prediction
The sequence of HLAE_HUMAN returned 5 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 310 320 330 + | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | IAIVGIIAGLVLLGSVVSGAVVAAVIWRKK | 6.8 | -47.2° | 1.3 | 45.0 | -69.3 |
| Model 2 | IAIVGIIAGLVLLGSVVSGAVVAAVIWRKK | 7.3 | -51.0° | 2.4 | 45.0 | -47.4 |
| Model 3 | IAIVGIIAGLVLLGSVVSGAVVAAVIWRKK | 7.1 | -52.0° | 0.6 | 48.2 | -44.6 |
| Model 4 | IAIVGIIAGLVLLGSVVSGAVVAAVIWRKK | 7.3 | -51.4° | 4.4 | 40.0 | -21.6 |
| Model 5 | IAIVGIIAGLVLLGSVVSGAVVAAVIWRKK | 7.3 | -22.0° | 4.7 | 37.0 | -6.6 |
| Prolines* | IPIVGIIAGLVLLGSVVSGAVVAAVIWRKK |
* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 318, VAL, HA | A, 317, SER, O | 3.17Å |
| B, 321, GLY, HA1 | A, 318, VAL, O | 2.79Å |
| B, 322, ALA, HA | A, 321, GLY, O | 3.09Å |
| A, 318, VAL, HA | B, 317, SER, O | 3.17Å |
| A, 321, GLY, HA1 | B, 318, VAL, O | 2.79Å |
| A, 322, ALA, HA | B, 321, GLY, O | 3.09Å |
