Tissue factor

UniProt data

UniProt name: TF_HUMAN (P13726)

Gene name: F3

Organism: Homo sapiens (Human).

Function: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. {ECO:0000269|PubMed:12652293}.

Subcellular location: Isoform 2: Secreted {ECO:0000269|PubMed:12652293}.

Transmembrane domains:

  1. 252-274, 23 AA, Helical. {ECO:0000255}.

Sequence: 295 AA

10 20 30 40 50 60 METPAWPRVP RPETAVARTL LLGWVFAQVA GASGTTNTVA AYNLTWKSTN FKTILEWEPK 70 80 90 100 110 120 PVNQVYTVQI STKSGDWKSK CFYTTDTECD LTDEIVKDVK QTYLARVFSY PAGNVESTGS 130 140 150 160 170 180 AGEPLYENSP EFTPYLETNL GQPTIQSFEQ VGTKVNVTVE DERTLVRRNN TFLSLRDVFG 190 200 210 220 230 240 KDLIYTLYYW KSSSSGKKTA KTNTNEFLID VDKGENYCFS VQAVIPSRTV NRKSTDSPVE 250 260 270 280 290 CMGQEKGEFR EIFYIIGAVV FVVIILVIIL AISLHKCRKA GVGQSWKENS PLNVS

CATM prediction

The sequence of TF_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   250       260       270     
 |    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 FREIFYIIGAVVFVVIILVIILAISLHKC 7.3 -55.2° 2.4 47.9 -5.8

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 254, TYR, HA A, 253, PHE, O 3.48Å
B, 257, GLY, HA1 A, 254, TYR, O 3.25Å
A, 254, TYR, HA B, 253, PHE, O 3.48Å
A, 257, GLY, HA1 B, 254, TYR, O 3.25Å