Carcinoembryonic antigen-related cell adhesion molecule 1 {ECO:0000303|Ref.8}

UniProt data

UniProt name: CEAM1_HUMAN (P13688)

Gene name: CEACAM1 {ECO:0000312|HGNC:HGNC:1814}

Organism: Homo sapiens (Human).

Function: Isoform 8: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Promotes populations of T cells regulating IgA production and secretion associated with control of the commensal microbiota and resistance to enteropathogens (By similarity). {ECO:0000250|UniProtKB:P16573, ECO:0000250|UniProtKB:P31809}.

Subcellular location: Isoform 8: Cell membrane {ECO:0000269|PubMed:14522961}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P16573}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:14522961}. Lateral cell membrane {ECO:0000250|UniProtKB:P16573}. Apical cell membrane {ECO:0000250|UniProtKB:P16573}. Basal cell membrane {ECO:0000250|UniProtKB:P16573}. Cell junction {ECO:0000269|PubMed:8018919}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P16573}. Note=Predominantly localized to the lateral cell membranes. Found as a mixture of monomer, dimer and oligomer in the plasma membrane. Occurs predominantly as cis- dimers and/or small cis-oligomers in the cell junction regions (By similarity). Co-localizes with ANXA2 in secretory vesicles and with S100A10/p11 at the plasma membrane (PubMed:14522961). {ECO:0000250|UniProtKB:P16573, ECO:0000269|PubMed:14522961}.

Transmembrane domains:

  1. 429-452, 24 AA, Helical. {ECO:0000255}.

Sequence: 526 AA

10 20 30 40 50 60 MGHLSAPLHR VRVPWQGLLL TASLLTFWNP PTTAQLTTES MPFNVAEGKE VLLLVHNLPQ 70 80 90 100 110 120 QLFGYSWYKG ERVDGNRQIV GYAIGTQQAT PGPANSGRET IYPNASLLIQ NVTQNDTGFY 130 140 150 160 170 180 TLQVIKSDLV NEEATGQFHV YPELPKPSIS SNNSNPVEDK DAVAFTCEPE TQDTTYLWWI 190 200 210 220 230 240 NNQSLPVSPR LQLSNGNRTL TLLSVTRNDT GPYECEIQNP VSANRSDPVT LNVTYGPDTP 250 260 270 280 290 300 TISPSDTYYR PGANLSLSCY AASNPPAQYS WLINGTFQQS TQELFIPNIT VNNSGSYTCH 310 320 330 340 350 360 ANNSVTGCNR TTVKTIIVTE LSPVVAKPQI KASKTTVTGD KDSVNLTCST NDTGISIRWF 370 380 390 400 410 420 FKNQSLPSSE RMKLSQGNTT LSINPVKRED AGTYWCEVFN PISKNQSDPI MLNVNYNALP 430 440 450 460 470 480 QENGLSPGAI AGIVIGVVAL VALIAVALAC FLHFGKTGRA SDQRDLTEHK PSVSNHTQDH 490 500 510 520 SNDPPNKMNE VTYSTLNFEA QQPTQPTSAS PSLTATEIIY SEVKKQ

CATM prediction

The sequence of CEAM1_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      430       440       450   
    |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 SAGAIAGIVIGVVALVALIAVALACFLHFG 6.5 -31.1° 4.1 50.9 -28.2
Model 2 SAGAIAGIVIGVVALVALIAVALACFLHFG 6.2 -45.0° 2.7 61.3 -23.7
Model 3 SAGAIAGIVIGVVALVALIAVALACFLHFG 6.6 -54.0° 4.8 41.0 -12.9
Model 4 SAGAIAGIVIGVVALVALIAVALACFLHFG 7.0 +54.0° 3.3 80.0 -4.7
Prolines* SPGAIAGIVIGVVALVALIAVALACFLHFG          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 432, GLY, HA1 A, 429, ALA, O 2.88Å
B, 433, ILE, HA A, 432, GLY, O 3.30Å
A, 432, GLY, HA1 B, 429, ALA, O 2.88Å
A, 433, ILE, HA B, 432, GLY, O 3.30Å