UniProt data
UniProt name: NCAM1_HUMAN (P13591)
Gene name: NCAM1; Synonyms=NCAM
Organism: Homo sapiens (Human).
Function: (Microbial infection) Acts as a receptor for rabies virus. {ECO:0000269|PubMed:9696812}.
Subcellular location: Isoform 6: Secreted {ECO:0000305}.
Transmembrane domains:
- 719-739, 21 AA, Helical. {ECO:0000255}.
Sequence: 858 AA
10 20 30 40 50 60
MLQTKDLIWT LFFLGTAVSL QVDIVPSQGE ISVGESKFFL CQVAGDAKDK DISWFSPNGE
70 80 90 100 110 120
KLTPNQQRIS VVWNDDSSST LTIYNANIDD AGIYKCVVTG EDGSESEATV NVKIFQKLMF
130 140 150 160 170 180
KNAPTPQEFR EGEDAVIVCD VVSSLPPTII WKHKGRDVIL KKDVRFIVLS NNYLQIRGIK
190 200 210 220 230 240
KTDEGTYRCE GRILARGEIN FKDIQVIVNV PPTIQARQNI VNATANLGQS VTLVCDAEGF
250 260 270 280 290 300
PEPTMSWTKD GEQIEQEEDD EKYIFSDDSS QLTIKKVDKN DEAEYICIAE NKAGEQDATI
310 320 330 340 350 360
HLKVFAKPKI TYVENQTAME LEEQVTLTCE ASGDPIPSIT WRTSTRNISS EEKASWTRPE
370 380 390 400 410 420
KQETLDGHMV VRSHARVSSL TLKSIQYTDA GEYICTASNT IGQDSQSMYL EVQYAPKLQG
430 440 450 460 470 480
PVAVYTWEGN QVNITCEVFA YPSATISWFR DGQLLPSSNY SNIKIYNTPS ASYLEVTPDS
490 500 510 520 530 540
ENDFGNYNCT AVNRIGQESL EFILVQADTP SSPSIDQVEP YSSTAQVQFD EPEATGGVPI
550 560 570 580 590 600
LKYKAEWRAV GEEVWHSKWY DAKEASMEGI VTIVGLKPET TYAVRLAALN GKGLGEISAA
610 620 630 640 650 660
SEFKTQPVQG EPSAPKLEGQ MGEDGNSIKV NLIKQDDGGS PIRHYLVRYR ALSSEWKPEI
670 680 690 700 710 720
RLPSGSDHVM LKSLDWNAEY EVYVVAENQQ GKSKAAHFVF RTSAQPTAIP ANGSPTSGLS
730 740 750 760 770 780
TGAIVGILIV IFVLLLVVVD ITCYFLNKCG LFMCIAVNLC GKAGPGAKGK DMEEGKAAFS
790 800 810 820 830 840
KDESKEPIVE VRTEEERTPN HDGGKHTEPN ETTPLTEPEK GPVEAKPECQ ETETKPAPAE
850
VKTVPNDATQ TKENESKA
CATM prediction
The sequence of NCAM1_HUMAN returned 3 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 720 730 740 | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | TSGLSTGAIVGILIVIFVLLLVVVDIT | 6.7 | -25.0° | 5.5 | 50.0 | -27.9 |
| Model 2 | TSGLSTGAIVGILIVIFVLLLVVVDIT | 6.5 | -38.0° | 5.0 | 59.0 | -12.4 |
| Model 3 | TSGLSTGAIVGILIVIFVLLLVVVDIT | 6.4 | -51.0° | 6.0 | 44.9 | -4.1 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 722, GLY, HA1 | A, 719, LEU, O | 3.37Å |
| A, 722, GLY, HA1 | B, 719, LEU, O | 3.37Å |
