Platelet glycoprotein Ib beta chain

UniProt data

UniProt name: GP1BB_HUMAN (P13224)

Gene name: GP1BB

Organism: Homo sapiens (Human).

Function: Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 148-172, 25 AA, Helical. {ECO:0000255}.

Sequence: 206 AA

10 20 30 40 50 60 MGSGPRGALS LLLLLLAPPS RPAAGCPAPC SCAGTLVDCG RRGLTWASLP TAFPVDTTEL 70 80 90 100 110 120 VLTGNNLTAL PPGLLDALPA LRTAHLGANP WRCDCRLVPL RAWLAGRPER APYRDLRCVA 130 140 150 160 170 180 PPALRGRLLP YLAEDELRAA CAPGPLCWGA LAAQLALLGL GLLHALLLVL LLCRLRRLRA 190 200 RARARAAARL SLTDPLVAER AGTDES

CATM prediction

The sequence of GP1BB_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       150       160       170   
+    |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 ALCWGALAAQLALLGLGLLHALLLVLLLCRL 7.2 -49.1° 1.9 44.0 -24.9
Prolines* PLCWGALAAQLALLGLGLLHALLLVLLLCRL          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 161, GLY, HA1 A, 158, LEU, O 3.24Å
B, 162, LEU, HA A, 161, GLY, O 3.33Å
A, 161, GLY, HA1 B, 158, LEU, O 3.24Å
A, 162, LEU, HA B, 161, GLY, O 3.33Å