Interferon-induced transmembrane protein 1

UniProt data

UniProt name: IFM1_HUMAN (P13164)

Gene name: IFITM1; Synonyms=CD225, IFI17

Organism: Homo sapiens (Human).

Function: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein- mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. {ECO:0000269|PubMed:16847454, ECO:0000269|PubMed:20064371, ECO:0000269|PubMed:20838853, ECO:0000269|PubMed:21177806, ECO:0000269|PubMed:21253575, ECO:0000269|PubMed:21976647, ECO:0000269|PubMed:22479637, ECO:0000269|PubMed:22634173}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:19499152, ECO:0000269|PubMed:25105503}; Single-pass membrane protein {ECO:0000269|PubMed:19499152}.

Transmembrane domains:

  1. 87-107, 21 AA, Helical. {ECO:0000255}.

Sequence: 125 AA

10 20 30 40 50 60 MHKEEHEVAV LGPPPSTILP RSTVINIHSE TSVPDHVVWS LFNTLFLNWC CLGFIAFAYS 70 80 90 100 110 120 VKSRDRKMVG DVTGAQAYAS TAKCLNIWAL ILGILMTIGF ILLLVFGSVT VYHIMLQIIQ EKRGY

CATM prediction

The sequence of IFM1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        90        100       1
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 CLNIWALILGILMTIGFILLLVFGSVT 7.4 -51.0° 3.3 48.0 -20.8

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 90, LEU, HA A, 89, ALA, O 3.25Å
B, 93, GLY, HA1 A, 90, LEU, O 3.21Å
B, 94, ILE, HA A, 97, THR, OG1 2.63Å
A, 90, LEU, HA B, 89, ALA, O 3.25Å
A, 93, GLY, HA1 B, 90, LEU, O 3.21Å
A, 94, ILE, HA B, 97, THR, OG1 2.63Å