Cadherin-1

UniProt data

UniProt name: CADH1_HUMAN (P12830)

Gene name: CDH1; Synonyms=CDHE, UVO

Organism: Homo sapiens (Human).

Function: E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. {ECO:0000269|PubMed:16417575}.

Subcellular location: Cell junction. Cell membrane; Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Note=Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma- catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane.

Transmembrane domains:

  1. 710-730, 21 AA, Helical. {ECO:0000255}.

Sequence: 882 AA

10 20 30 40 50 60 MGPWSRSLSA LLLLLQVSSW LCQEPEPCHP GFDAESYTFT VPRRHLERGR VLGRVNFEDC 70 80 90 100 110 120 TGRQRTAYFS LDTRFKVGTD GVITVKRPLR FHNPQIHFLV YAWDSTYRKF STKVTLNTVG 130 140 150 160 170 180 HHHRPPPHQA SVSGIQAELL TFPNSSPGLR RQKRDWVIPP ISCPENEKGP FPKNLVQIKS 190 200 210 220 230 240 NKDKEGKVFY SITGQGADTP PVGVFIIERE TGWLKVTEPL DRERIATYTL FSHAVSSNGN 250 260 270 280 290 300 AVEDPMEILI TVTDQNDNKP EFTQEVFKGS VMEGALPGTS VMEVTATDAD DDVNTYNAAI 310 320 330 340 350 360 AYTILSQDPE LPDKNMFTIN RNTGVISVVT TGLDRESFPT YTLVVQAADL QGEGLSTTAT 370 380 390 400 410 420 AVITVTDTND NPPIFNPTTY KGQVPENEAN VVITTLKVTD ADAPNTPAWE AVYTILNDDG 430 440 450 460 470 480 GQFVVTTNPV NNDGILKTAK GLDFEAKQQY ILHVAVTNVV PFEVSLTTST ATVTVDVLDV 490 500 510 520 530 540 NEAPIFVPPE KRVEVSEDFG VGQEITSYTA QEPDTFMEQK ITYRIWRDTA NWLEINPDTG 550 560 570 580 590 600 AISTRAELDR EDFEHVKNST YTALIIATDN GSPVATGTGT LLLILSDVND NAPIPEPRTI 610 620 630 640 650 660 FFCERNPKPQ VINIIDADLP PNTSPFTAEL THGASANWTI QYNDPTQESI ILKPKMALEV 670 680 690 700 710 720 GDYKINLKLM DNQNKDQVTT LEVSVCDCEG AAGVCRKAQP VEAGLQIPAI LGILGGILAL 730 740 750 760 770 780 LILILLLLLF LRRRAVVKEP LLPPEDDTRD NVYYYDEEGG GEEDQDFDLS QLHRGLDARP 790 800 810 820 830 840 EVTRNDVAPT LMSVPRYLPR PANPDEIGNF IDENLKAADT DPTAPPYDSL LVFDYEGSGS 850 860 870 880 EAASLSSLNS SESDKDQDYD YLNEWGNRFK KLADMYGGGE DD

CATM prediction

The sequence of CADH1_HUMAN returned 5 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     710       720       730 
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 IAAILGILGGILALLILILLLLLFLRR 7.1 +52.0° 1.8 1.0 -13.9
Model 2 IAAILGILGGILALLILILLLLLFLRR 7.2 -30.0° 5.7 37.0 -11.6
Model 3 IAAILGILGGILALLILILLLLLFLRR 6.9 -45.0° 4.0 39.0 -2.8
Model 4 IAAILGILGGILALLILILLLLLFLRR 6.8 -47.8° 1.0 37.1 -1.5
Model 5 IAAILGILGGILALLILILLLLLFLRR 7.0 +54.1° 3.3 79.7 -0.6
Prolines* IPAILGILGGILALLILILLLLLFLRR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 712, GLY, HA2 A, 711, LEU, O 3.43Å
A, 712, GLY, HA2 B, 711, LEU, O 3.43Å