High affinity immunoglobulin epsilon receptor subunit alpha

UniProt data

UniProt name: FCERA_HUMAN (P12319)

Gene name: FCER1A; Synonyms=FCE1A

Organism: Homo sapiens (Human).

Function: Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.

Subcellular location: Cell membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 206-224, 19 AA, Helical. {ECO:0000255}.

Sequence: 257 AA

10 20 30 40 50 60 MAPAMESPTL LCVALLFFAP DGVLAVPQKP KVSLNPPWNR IFKGENVTLT CNGNNFFEVS 70 80 90 100 110 120 STKWFHNGSL SEETNSSLNI VNAKFEDSGE YKCQHQQVNE SEPVYLEVFS DWLLLQASAE 130 140 150 160 170 180 VVMEGQPLFL RCHGWRNWDV YKVIYYKDGE ALKYWYENHN ISITNATVED SGTYYCTGKV 190 200 210 220 230 240 WQLDYESEPL NITVIKAPRE KYWLQFFIPL LVVILFAVDT GLFISTQQQV TFLLKIKRTR 250 KGFRLLNPHP KPNPKNN

CATM prediction

The sequence of FCERA_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         210       220     
  +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 WLQFFIALLVVILFAVDTGLFISTQ 6.9 -46.0° 2.7 47.0 -31.4
Prolines* WLQFFIPLLVVILFAVDTGLFISTQ          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 218, VAL, HA A, 217, ALA, O 2.89Å
B, 221, GLY, HA1 A, 218, VAL, O 2.86Å
B, 222, LEU, HA A, 221, GLY, O 3.46Å
A, 218, VAL, HA B, 217, ALA, O 2.89Å
A, 221, GLY, HA1 B, 218, VAL, O 2.86Å
A, 222, LEU, HA B, 221, GLY, O 3.46Å