Low affinity immunoglobulin gamma Fc region receptor II-a

UniProt data

UniProt name: FCG2A_HUMAN (P12318)

Gene name: FCGR2A; Synonyms=CD32, FCG2, FCGR2A1, IGFR2

Organism: Homo sapiens (Human).

Function: Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens. {ECO:0000269|PubMed:19011614}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:19011614}; Single-pass type I membrane protein {ECO:0000269|PubMed:19011614}.

Transmembrane domains:

  1. 218-240, 23 AA, Helical. {ECO:0000255}.

Sequence: 317 AA

10 20 30 40 50 60 MTMETQMSQN VCPRNLWLLQ PLTVLLLLAS ADSQAAAPPK AVLKLEPPWI NVLQEDSVTL 70 80 90 100 110 120 TCQGARSPES DSIQWFHNGN LIPTHTQPSY RFKANNNDSG EYTCQTGQTS LSDPVHLTVL 130 140 150 160 170 180 SEWLVLQTPH LEFQEGETIM LRCHSWKDKP LVKVTFFQNG KSQKFSHLDP TFSIPQANHS 190 200 210 220 230 240 HSGDYHCTGN IGYTLFSSKP VTITVQVPSM GSSSPMGIIV AVVIATAVAA IVAAVVALIY 250 260 270 280 290 300 CRKKRISANS TDPVKAAQFE PPGRQMIAIR KRQLEETNND YETADGGYMT LNPRAPTDDD 310 KNIYLTLPPN DHVNSNN

CATM prediction

The sequence of FCG2A_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       220       230       240 
+    |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 AMGIIVAVVIATAVAAIVAAVVALIYCRK 7.2 -37.2° 2.3 35.8 -5.2
Prolines* PMGIIVAVVIATAVAAIVAAVVALIYCRK          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 230, ALA, HA A, 229, ALA, O 3.50Å
B, 234, ALA, HA A, 233, ALA, O 3.43Å
A, 230, ALA, HA B, 229, ALA, O 3.50Å
A, 234, ALA, HA B, 233, ALA, O 3.43Å