Lysosome-associated membrane glycoprotein 1

UniProt data

UniProt name: LAMP1_HUMAN (P11279)

Gene name: LAMP1

Organism: Homo sapiens (Human).

Function: Acts as a receptor for Lassa virus protein. {ECO:0000269|PubMed:24970085}.

Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P05300}; Single-pass type I membrane protein {ECO:0000255}. Endosome membrane; Single-pass type I membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:17897319}; Single-pass type I membrane protein {ECO:0000255}. Late endosome {ECO:0000269|PubMed:16176980}. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane (By similarity). Colocalizes with OSBPL1A at the late endosome (PubMed:16176980). {ECO:0000250|UniProtKB:P05300, ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:17897319}.

Transmembrane domains:

  1. 383-405, 23 AA, Helical. {ECO:0000255|PROSITE- ProRule:PRU00740}.

Sequence: 417 AA

10 20 30 40 50 60 MAAPGSARRP LLLLLLLLLL GLMHCASAAM FMVKNGNGTA CIMANFSAAF SVNYDTKSGP 70 80 90 100 110 120 KNMTFDLPSD ATVVLNRSSC GKENTSDPSL VIAFGRGHTL TLNFTRNATR YSVQLMSFVY 130 140 150 160 170 180 NLSDTHLFPN ASSKEIKTVE SITDIRADID KKYRCVSGTQ VHMNNVTVTL HDATIQAYLS 190 200 210 220 230 240 NSSFSRGETR CEQDRPSPTT APPAPPSPSP SPVPKSPSVD KYNVSGTNGT CLLASMGLQL 250 260 270 280 290 300 NLTYERKDNT TVTRLLNINP NKTSASGSCG AHLVTLELHS EGTTVLLFQF GMNASSSRFF 310 320 330 340 350 360 LQGIQLNTIL PDARDPAFKA ANGSLRALQA TVGNSYKCNA EEHVRVTKAF SVNIFKVWVQ 370 380 390 400 410 AFKVEGGQFG SVEECLLDEN SMLIPIAVGG ALAGLVLIVL IAYLVGRKRS HAGYQTI

CATM prediction

The sequence of LAMP1_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  380       390       400      
|    +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 NSMLIAIAVGGALAGLVLIVLIAYLVGRK 6.9 -50.0° 2.8 47.2 -21.8
Model 2 NSMLIAIAVGGALAGLVLIVLIAYLVGRK 6.7 -48.2° 1.0 37.3 -16.0
Model 3 NSMLIAIAVGGALAGLVLIVLIAYLVGRK 7.1 -43.2° -0.0 34.2 -11.5
Prolines* NSMLIPIAVGGALAGLVLIVLIAYLVGRK          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 386, ILE, HA A, 385, ALA, O 2.94Å
B, 389, GLY, HA1 A, 386, ILE, O 2.85Å
A, 386, ILE, HA B, 385, ALA, O 2.94Å
A, 389, GLY, HA1 B, 386, ILE, O 2.85Å