Integrin alpha-M

UniProt data

UniProt name: ITAM_HUMAN (P11215)

Gene name: ITGAM; Synonyms=CD11B, CR3A

Organism: Homo sapiens (Human).

Function: Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 1105-1128, 24 AA, Helical. {ECO:0000255}.

Sequence: 1152 AA

10 20 30 40 50 60 MALRVLLLTA LTLCHGFNLD TENAMTFQEN ARGFGQSVVQ LQGSRVVVGA PQEIVAANQR 70 80 90 100 110 120 GSLYQCDYST GSCEPIRLQV PVEAVNMSLG LSLAATTSPP QLLACGPTVH QTCSENTYVK 130 140 150 160 170 180 GLCFLFGSNL RQQPQKFPEA LRGCPQEDSD IAFLIDGSGS IIPHDFRRMK EFVSTVMEQL 190 200 210 220 230 240 KKSKTLFSLM QYSEEFRIHF TFKEFQNNPN PRSLVKPITQ LLGRTHTATG IRKVVRELFN 250 260 270 280 290 300 ITNGARKNAF KILVVITDGE KFGDPLGYED VIPEADREGV IRYVIGVGDA FRSEKSRQEL 310 320 330 340 350 360 NTIASKPPRD HVFQVNNFEA LKTIQNQLRE KIFAIEGTQT GSSSSFEHEM SQEGFSAAIT 370 380 390 400 410 420 SNGPLLSTVG SYDWAGGVFL YTSKEKSTFI NMTRVDSDMN DAYLGYAAAI ILRNRVQSLV 430 440 450 460 470 480 LGAPRYQHIG LVAMFRQNTG MWESNANVKG TQIGAYFGAS LCSVDVDSNG STDLVLIGAP 490 500 510 520 530 540 HYYEQTRGGQ VSVCPLPRGR ARWQCDAVLY GEQGQPWGRF GAALTVLGDV NGDKLTDVAI 550 560 570 580 590 600 GAPGEEDNRG AVYLFHGTSG SGISPSHSQR IAGSKLSPRL QYFGQSLSGG QDLTMDGLVD 610 620 630 640 650 660 LTVGAQGHVL LLRSQPVLRV KAIMEFNPRE VARNVFECND QVVKGKEAGE VRVCLHVQKS 670 680 690 700 710 720 TRDRLREGQI QSVVTYDLAL DSGRPHSRAV FNETKNSTRR QTQVLGLTQT CETLKLQLPN 730 740 750 760 770 780 CIEDPVSPIV LRLNFSLVGT PLSAFGNLRP VLAEDAQRLF TALFPFEKNC GNDNICQDDL 790 800 810 820 830 840 SITFSFMSLD CLVVGGPREF NVTVTVRNDG EDSYRTQVTF FFPLDLSYRK VSTLQNQRSQ 850 860 870 880 890 900 RSWRLACESA SSTEVSGALK STSCSINHPI FPENSEVTFN ITFDVDSKAS LGNKLLLKAN 910 920 930 940 950 960 VTSENNMPRT NKTEFQLELP VKYAVYMVVT SHGVSTKYLN FTASENTSRV MQHQYQVSNL 970 980 990 1000 1010 1020 GQRSLPISLV FLVPVRLNQT VIWDRPQVTF SENLSSTCHT KERLPSHSDF LAELRKAPVV 1030 1040 1050 1060 1070 1080 NCSIAVCQRI QCDIPFFGIQ EEFNATLKGN LSFDWYIKTS HNHLLIVSTA EILFNDSVFT 1090 1100 1110 1120 1130 1140 LLPGQGAFVR SQTETKVEPF EVPNPLPLIV GSSVGGLLLL ALITAALYKL GFFKRQYKDM 1150 MSEGGPPGAE PQ

CATM prediction

The sequence of ITAM_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          1110      1120      11
   +    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 VANALALIVGSSVGGLLLLALITAALYKLG 6.6 -51.8° 5.2 40.2 -23.6
Model 2 VANALALIVGSSVGGLLLLALITAALYKLG 7.2 -30.3° 5.7 37.0 -22.3
Model 3 VANALALIVGSSVGGLLLLALITAALYKLG 7.2 -44.0° 1.8 58.8 -19.0
Prolines* VPNPLPLIVGSSVGGLLLLALITAALYKLG          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1111, GLY, HA1 A, 1108, LEU, O 3.18Å
B, 1112, SER, HA A, 1111, GLY, O 2.54Å
B, 1115, GLY, HA1 A, 1112, SER, O 2.95Å
A, 1111, GLY, HA1 B, 1108, LEU, O 3.18Å
A, 1112, SER, HA B, 1111, GLY, O 2.54Å
A, 1115, GLY, HA1 B, 1112, SER, O 2.95Å